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Open AccessArticle

New Zealand Bitter Hops Extract Reduces Hunger During a 24 h Water Only Fast

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The New Zealand Institute for Plant and Food Research Limited, Auckland 1025, New Zealand
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The New Zealand Institute for Plant and Food Research Limited, Palmerston North 4442, New Zealand
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The New Zealand Institute for Plant and Food Research Limited, Hamilton 3240, New Zealand
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Author to whom correspondence should be addressed.
Nutrients 2019, 11(11), 2754; https://doi.org/10.3390/nu11112754
Received: 24 October 2019 / Revised: 6 November 2019 / Accepted: 9 November 2019 / Published: 13 November 2019
Intermittent fasting improves metabolic and cardiac health. However, increased hunger towards the end of the fasting period may affect compliance and limit its application. Our aim was to determine the effect of anorexigenic agent co-therapy on subjective ratings of appetite during the 16–24 h period of a day-long water-only intermittent fast. Thirty adult men were recruited and required to fast for 24 h from 18:00 h to 18:00 h on the same day of the week for three subsequent weeks. Treatments of either a placebo or one of two doses (high dose; HD: 250 mg or low dose; LD: 100 mg) of a bitter hops-based appetite suppressant (Amarasate®) were given twice per day at 16 and 20 h into the fast. From 18–24 h of the 24 h fast, both the HD and LD treatment groups exhibited a statistically significant (p < 0.05) > 10% reduction in hunger. Additionally, the expected lunchtime increase in hunger that was present in the placebo group (12:00 h) was absent in both the HD and LD groups. These data suggest that appetite suppressant co-therapy may be useful in reducing hunger during intermittent fasting, and show that bitter compounds may regulate appetite independently of meal timing. View Full-Text
Keywords: Intermittent fasting; time–restricted eating; bitter taste receptors; appetite; satiety; bitter brake; Amarasate®; water fasting; dietary supplement; calorie restriction Intermittent fasting; time–restricted eating; bitter taste receptors; appetite; satiety; bitter brake; Amarasate®; water fasting; dietary supplement; calorie restriction
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Walker, E.; Lo, K.; Tham, S.; Pahl, M.; Lomiwes, D.; Cooney, J.; Wohlers, M.; Gopal, P. New Zealand Bitter Hops Extract Reduces Hunger During a 24 h Water Only Fast. Nutrients 2019, 11, 2754.

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