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Review

Improving Health-Promoting Effects of Food-Derived Bioactive Peptides through Rational Design and Oral Delivery Strategies

Department of Biotechnology, Instituto de Agroquímica y Tecnología de Alimentos (IATA), Consejo Superior de Investigaciones Científicas (CSIC), 46980 Paterna, Valencia, Spain
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Author to whom correspondence should be addressed.
Present address: Fungal Physiology, Westerdijk Fungal Biodiversity Institute & Fungal Molecular Physiology, Utrecht University, Uppsalalaan 8, 3584 CT Utrecht, The Netherlands.
Nutrients 2019, 11(10), 2545; https://doi.org/10.3390/nu11102545
Received: 12 September 2019 / Revised: 10 October 2019 / Accepted: 15 October 2019 / Published: 22 October 2019
(This article belongs to the Special Issue Effect of Bioactive Peptides on Human Health)
Over the last few decades, scientific interest in food-derived bioactive peptides has grown as an alternative to pharmacological treatments in the control of lifestyle-associated diseases, which represent a serious health problem worldwide. Interest has been directed towards the control of hypertension, the management of type 2 diabetes and oxidative stress. Many food-derived antihypertensive peptides act primarily by inhibiting angiotensin I-converting enzyme (ACE), and to a lesser extent, renin enzyme activities. Antidiabetic peptides mainly inhibit dipeptidyl peptidase-IV (DPP-IV) activity, whereas antioxidant peptides act through inactivation of reactive oxygen species, free radicals scavenging, chelation of pro-oxidative transition metals and promoting the activities of intracellular antioxidant enzymes. However, food-derived bioactive peptides have intrinsic weaknesses, including poor chemical and physical stability and a short circulating plasma half-life that must be addressed for their application as nutraceuticals or in functional foods. This review summarizes the application of common pharmaceutical approaches such as rational design and oral delivery strategies to improve the health-promoting effects of food-derived bioactive peptides. We review the structural requirements of antihypertensive, antidiabetic and antioxidant peptides established by integrated computational methods and provide relevant examples of effective oral delivery systems to enhance solubility, stability and permeability of bioactive peptides. View Full-Text
Keywords: nutraceuticals; functional foods; food-derived bioactive peptides; hypertension; type 2 diabetes; oxidative stress; structural requirements; computational methods; rationally designed peptides; oral delivery strategies nutraceuticals; functional foods; food-derived bioactive peptides; hypertension; type 2 diabetes; oxidative stress; structural requirements; computational methods; rationally designed peptides; oral delivery strategies
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MDPI and ACS Style

Manzanares, P.; Gandía, M.; Garrigues, S.; Marcos, J.F. Improving Health-Promoting Effects of Food-Derived Bioactive Peptides through Rational Design and Oral Delivery Strategies. Nutrients 2019, 11, 2545. https://doi.org/10.3390/nu11102545

AMA Style

Manzanares P, Gandía M, Garrigues S, Marcos JF. Improving Health-Promoting Effects of Food-Derived Bioactive Peptides through Rational Design and Oral Delivery Strategies. Nutrients. 2019; 11(10):2545. https://doi.org/10.3390/nu11102545

Chicago/Turabian Style

Manzanares, Paloma, Mónica Gandía, Sandra Garrigues, and Jose F. Marcos 2019. "Improving Health-Promoting Effects of Food-Derived Bioactive Peptides through Rational Design and Oral Delivery Strategies" Nutrients 11, no. 10: 2545. https://doi.org/10.3390/nu11102545

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