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Open AccessArticle

Food–Drug Interaction between the Adlay Bran Oil and Drugs in Rats

1
Department of Nutrition, China Medical University, 91 Hsueh-shih Road, Taichung 404, Taiwan
2
Graduate Institute of Food Science and Technology, Center for Food and Biomolecules, College of Bioresources and Agriculture, National Taiwan University, 1 Roosevelt Road, Sec. 4, Taipei 106, Taiwan
*
Author to whom correspondence should be addressed.
Nutrients 2019, 11(10), 2473; https://doi.org/10.3390/nu11102473
Received: 8 September 2019 / Revised: 29 September 2019 / Accepted: 14 October 2019 / Published: 15 October 2019
(This article belongs to the Special Issue Drug-Nutrition Interactions)
Adlay (Coix lachryma-jobi L. var. ma-yuen Stapf) contains various phytonutrients for treating many diseases in Asia. To investigate whether orally administered adlay bran oil (ABO) can cause drug interactions, the effects of ABO on the pharmacokinetics of five cytochrome P450 (CYP) probe drugs were evaluated. Rats were given a single oral dose (2.5 mL/kg BW) of ABO 1 h before administration of a drug cocktail either orally or intravenously, and blood was collected at various time points. A single oral dose of ABO administration did not affect the pharmacokinetics of five probe drugs when given as a drug cocktail intravenously. However, ABO increased plasma theophylline (+28.4%), dextromethorphan (+48.7%), and diltiazem (+46.7%) when co-administered an oral drug cocktail. After 7 days of feeding with an ABO-containing diet, plasma concentrations of theophylline (+45.4%) and chlorzoxazone (+53.6%) were increased after the oral administration of the drug cocktail. The major CYP enzyme activities in the liver and intestinal tract were not affected by ABO treatment. Results from this study indicate that a single oral dose or short-term administration of ABO may increase plasma drug concentrations when ABO is given concomitantly with drugs. ABO is likely to enhance intestinal drug absorption. Therefore, caution is needed to avoid food–drug interactions between ABO and co-administered drugs. View Full-Text
Keywords: adlay; adlay bran oil; cytochrome P450; food–drug interactions; rats adlay; adlay bran oil; cytochrome P450; food–drug interactions; rats
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Yao, H.-T.; Lin, J.-H.; Liu, Y.-T.; Li, M.-L.; Chiang, W. Food–Drug Interaction between the Adlay Bran Oil and Drugs in Rats. Nutrients 2019, 11, 2473.

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