Next Article in Journal
The Association between Milk and Dairy Products Consumption and Nutrient Intake Adequacy among Japanese Adults: Analysis of the 2016 National Health and Nutrition Survey
Next Article in Special Issue
Impact of Bacterial Translocation on Sarcopenia in Patients with Decompensated Cirrhosis
Previous Article in Journal
Longitudinal Associations between Monetary Value of the Diet, DASH Diet Score and the Allostatic Load among Middle-Aged Urban Adults
Previous Article in Special Issue
The Effect of 12 Weeks of β-Hydroxy-β-Methyl-Butyrate Supplementation after Liver Transplantation: A Pilot Randomized Controlled Study
Open AccessArticle

A Nutraceutical Rich in Docosahexaenoic Acid Improves Portal Hypertension in a Preclinical Model of Advanced Chronic Liver Disease

Barcelona Liver Bioservices, 08036 Barcelona, Spain
Biochemistry and Molecular Biomedicine Department, Faculty of Biology, University of Barcelona, 08036 Barcelona, Spain
Department of Cell Death and Proliferation, IIBB-CSIC/IDIBAPS, 08036 Barcelona, Spain
Liver Vascular Biology Research Group, IDIBAPS, 08036 Barcelona, Spain
CIBEREHD, 28029 Madrid, Spain
Hepatology, Department of Biomedical Research, University of Bern, 3012 Bern, Switzerland
Author to whom correspondence should be addressed.
Nutrients 2019, 11(10), 2358;
Received: 29 August 2019 / Revised: 25 September 2019 / Accepted: 29 September 2019 / Published: 3 October 2019
(This article belongs to the Special Issue Nutrition in Liver Cirrhosis and Liver Transplantation)
Inflammation and oxidative stress play a key role in the pathophysiology of advanced chronic liver disease (ACLD) and portal hypertension (PH). Considering the current lack of effective treatments, we evaluated an anti-inflammatory and antioxidant nutraceutical rich in docosahexaenoic acid (DHA) as a possible therapy for ACLD. We investigated the effects of two-week DHA supplementation (500 mg/kg) on hepatic fatty acids, PH, oxidative stress, inflammation, and hepatic stellate cell (HSC) phenotype in rats with ACLD. Additionally, the effects of DHA were evaluated in murine macrophages and human HSC. In contrast to vehicle-treated animals, cirrhotic rats receiving DHA reestablished a healthy hepatic fatty acid profile, which was associated with an improvement in PH. The mechanisms underlying this hemodynamic improvement included a reduction in oxidative stress and inflammation, as well as a marked HSC deactivation, confirmed in human HSC. Experiments with cultured macrophages showed that treatment with DHA protects against pro-inflammatory insults. The present preclinical study demonstrates that a nutraceutical rich in DHA significantly improves PH in chronic liver disease mainly by suppressing inflammation and oxidative stress-driven HSC activation, encouraging its evaluation as a new treatment for PH and cirrhosis. View Full-Text
Keywords: DHA; omega-3; liver fibrosis; liver cirrhosis; hepatic hemodynamics DHA; omega-3; liver fibrosis; liver cirrhosis; hepatic hemodynamics
Show Figures

Figure 1

MDPI and ACS Style

Boyer-Diaz, Z.; Domingo, J.C.; De Gregorio, E.; Manicardi, N.; Aristu-Zabalza, P.; Cordobilla, B.; Abad-Jordà, L.; Ortega-Ribera, M.; Fernández-Iglesias, A.; Marí, M.; Bosch, J.; Gracia-Sancho, J. A Nutraceutical Rich in Docosahexaenoic Acid Improves Portal Hypertension in a Preclinical Model of Advanced Chronic Liver Disease. Nutrients 2019, 11, 2358.

Show more citation formats Show less citations formats
Note that from the first issue of 2016, MDPI journals use article numbers instead of page numbers. See further details here.

Article Access Map by Country/Region

Search more from Scilit
Back to TopTop