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Erratum published on 13 February 2019, see Nutrients 2019, 11(2), 396.
Open AccessArticle

Status of Retinoids and Carotenoids and Associations with Clinical Outcomes in Maternal-Infant Pairs in Nigeria

1
College of Allied Health Professions Medical Nutrition Education, University of Nebraska Medical Center, Omaha, NE 68198-4045, USA
2
College of Public Health, University of Nebraska Medical Center, Omaha, NE 68198-4375, USA
3
Pediatrics 981205 Nebraska Medical Center, University of Nebraska Medical Center, Omaha, NE 68198-1205, USA
4
Department of Nutrition, Harvard School of Public Health 655 Huntington Avenue, Boston, MA 02215, USA
5
University of Abuja Teaching Hospital Gwagwalada-Zuba, Gwagwalada P.M.B. 228, Nigeria
*
Author to whom correspondence should be addressed.
Nutrients 2018, 10(9), 1286; https://doi.org/10.3390/nu10091286
Received: 23 August 2018 / Revised: 7 September 2018 / Accepted: 10 September 2018 / Published: 12 September 2018
(This article belongs to the Special Issue Vitamin A and Human Health)
Vitamin A is an essential nutrient in pregnancy, and other carotenoids have been independently associated with maternal-infant outcomes. The objective of this study was to quantify the status of vitamin A and carotenoids in Nigerian maternal-infant pairs at delivery, compare these to a cohort from a developed nation, and determine the impact on clinical outcomes. Maternal and cord blood samples were collected in 99 Nigerian mother-infant pairs. Concentrations of lutein + zeaxanthin, β-cryptoxanthin, lycopene, α- and β-carotenes, and retinol were measured using HPLC. Descriptive statistics were calculated and Spearman coefficients were used to assess correlations between maternal and cord measurements; Mann-Whitney tests were used to compare median plasma values between dichotomous variables. Linear regression models were used to adjust for relevant confounders. A p < 0.05 was considered statistically significant. Thirty-five percent of mothers had plasma retinol concentrations ≤0.70 µmol/L; 82% of infants had plasma retinol concentrations ≤0.70 µmol/L at delivery. Maternal and infant concentrations of vitamin A compounds were highly correlated and were associated with newborn growth and Apgar scores. Despite plasma concentrations of pro-vitamin A carotenoids higher than those reported in other populations, pregnant Nigerian women have a high prevalence of vitamin A deficiency. As vitamin A related compounds are modifiable by diet, future research determining the clinical impact of these compounds is warranted. View Full-Text
Keywords: vitamin A; carotenoids; lutein; β-carotene; pregnancy; maternal-child vitamin A; carotenoids; lutein; β-carotene; pregnancy; maternal-child
MDPI and ACS Style

Hanson, C.; Lyden, E.; Anderson-Berry, A.; Kocmich, N.; Rezac, A.; Delair, S.; Furtado, J.; Van Ormer, M.; Izevbigie, N.; Olateju, E.; Akaba, G.O.; Anigilaje, E.; Yunusa, T.; Obaro, S. Status of Retinoids and Carotenoids and Associations with Clinical Outcomes in Maternal-Infant Pairs in Nigeria. Nutrients 2018, 10, 1286.

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