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Nutrients 2018, 10(9), 1243; https://doi.org/10.3390/nu10091243

Serum Parathyroid Hormone, 25-Hydroxyvitamin D, and Risk of Alzheimer’s Disease: A Mendelian Randomization Study

1
Unit of Nutritional Epidemiology, Institute of Environmental Medicine, Karolinska Institutet, SE-171 77 Stockholm, Sweden
2
Stroke Research Group, Department of Clinical Neurosciences, University of Cambridge, Cambridge 01223, UK
3
Department of Surgical Sciences, Uppsala University, 75105 Uppsala, Sweden
*
Author to whom correspondence should be addressed.
Received: 17 August 2018 / Revised: 31 August 2018 / Accepted: 4 September 2018 / Published: 6 September 2018
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Abstract

We conducted Mendelian randomization analyses to investigate the associations of serum parathyroid hormone (S-PTH) and serum 25-hydroxyvitamin D (S-25OHD) concentrations with Alzheimer’s disease (AD). Five and seven single nucleotide polymorphisms associated with S-PTH and S-25OHD concentrations, respectively, were used as instrumental variables. Data for AD were acquired from the International Genomics of Alzheimer’s Project (17,008 AD cases and 37,154 controls). Genetically higher S-PTH concentrations were not associated with AD (odds ratio per standard deviation increase in S-PTH = 1.11; 95% CI 0.97–1.26; p = 0.12). In contrast, all seven 25OHD-increasing alleles were inversely associated with AD and two of the associations were statistically significant (p < 0.05). The odds ratio of AD per genetically-predicted one standard deviation increase in S-25OHD was 0.86 (95% CI 0.78–0.94; p = 0.002). This study provides evidence that vitamin D may play a role in AD but found no significant association between S-PTH and AD. View Full-Text
Keywords: Alzheimer’s disease; Mendelian randomization; parathyroid hormone; vitamin D Alzheimer’s disease; Mendelian randomization; parathyroid hormone; vitamin D
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Larsson, S.C.; Traylor, M.; Markus, H.S.; Michaëlsson, K. Serum Parathyroid Hormone, 25-Hydroxyvitamin D, and Risk of Alzheimer’s Disease: A Mendelian Randomization Study. Nutrients 2018, 10, 1243.

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