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Nutrients 2018, 10(9), 1227; https://doi.org/10.3390/nu10091227

The Antisecretory Factor in Plasma and Breast Milk in Breastfeeding Mothers—A Prospective Cohort Study in Sweden

1
Department of Clinical Science, Intervention and Technology, Karolinska Institutet, SE 141 86 Stockholm, Sweden
2
Department of Neonatology, Karolinska University Hospital, SE 171 76 Stockholm, Sweden
3
Department of Odontology, Pediatric dentistry, Umeå university, SE 901 87 Umeå, Sweden
4
Department of Clinical Sciences, Pediatrics, Umeå University, SE 901 87 Umeå, Sweden
*
Author to whom correspondence should be addressed.
Received: 31 July 2018 / Revised: 29 August 2018 / Accepted: 3 September 2018 / Published: 4 September 2018
(This article belongs to the Special Issue Breastfeeding and Human Lactation)
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Abstract

Inflammation and infection postpartum threaten the mother and her infant. Human milk provides a defense for the infant, but inflammatory complications like mastitis may lead to the cessation of breastfeeding. Antisecretory factor (AF) has a role in the regulation of secretory processes and inflammation. The objective of the study was to describe AF-levels in plasma and breast milk, and in relation to breast complications. Breastfeeding mothers (n = 95) were consecutively recruited at a Well Baby Clinic in Umeå, Sweden. At inclusion four weeks postpartum, samples of venous blood (10 mL) and breast milk (10 mL) were collected. Active AF was analyzed with ELISA using a monoclonal antibody mAb43, and was detected in all samples of plasma and breast milk with a positive correlation (Spearman coefficient = 0.40, p < 0.001; Pearson correlation = 0.34, p < 0.01). High AF-levels in plasma correlated with high AF-levels in breast milk. The results suggest a co-regulation between active AF in plasma and breastmilk, and/or a local regulation of AF in the breast. Further studies are needed to determine the pathways for the activation of AF-levels in breast milk and plasma. View Full-Text
Keywords: antisecretory factor; human milk; breast milk; breastfeeding; inflammation; lactoferrin; candida antisecretory factor; human milk; breast milk; breastfeeding; inflammation; lactoferrin; candida
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Gustafsson, A.; Granström, E.; Stecksén-Blicks, C.; West, C.E.; Silfverdal, S.-A. The Antisecretory Factor in Plasma and Breast Milk in Breastfeeding Mothers—A Prospective Cohort Study in Sweden. Nutrients 2018, 10, 1227.

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