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Nutrients 2018, 10(7), 945; https://doi.org/10.3390/nu10070945

Dietary Fiber Intake and Endometrial Cancer Risk: A Systematic Review and Meta-Analysis

1
School of Life Sciences, Shanghai University, 333 Nanchen Road, Shanghai 200444, China
2
CAS Key Laboratory of Nutrition, Metabolism and Food safety, Shanghai Institute of Nutrition and Health, Shanghai Institutes for Biological Sciences, University of Chinese Academy of Sciences, Chinese Academy of Sciences, 320 Yueyang Road, New Life Science Building, Room A1926, Shanghai 200031, China
3
DuPont Nutrition & Health, No. 10, Lane 280, Linhong Rd., Changning District, Shanghai 200335, China
4
Department of Nutrition Hygiene, Division of Health Risk Factor Monitoring and Control, Shanghai Municipal Center for Disease Control and Prevention, 1380 West Zhongshan Road, Changning District, Shanghai 200336, China
5
Macau Institute for Applied Research in Medicine and Health, Macau University of Science and Technology, Avenide Wai Long, Taipa, Macau
6
Department of Epidemiology, School of Public Health, Fudan University, 138 Yi Xue Yuan Road, Shanghai 200032, China
*
Author to whom correspondence should be addressed.
Received: 24 June 2018 / Revised: 19 July 2018 / Accepted: 20 July 2018 / Published: 22 July 2018
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Abstract

Epidemiological studies are inconclusive regarding the association between dietary fiber intake and endometrial cancer risk. Thus, we aimed to conduct a meta-analysis to clarify the association between dietary fiber and endometrial cancer risk. We searched the PubMed and ISI Web databases for relevant studies through March 2018. The association between dietary fiber and endometrial cancer risk was evaluated by conducting a meta-analysis including 3 cohort and 12 case–control studies. A significant negative association was observed between total dietary fiber intake and endometrial cancer risk in 11 case–control studies (odds ratios (OR) 0.76, 95% confidence interval (CI): 0.64–0.89, I2 = 35.2%, p = 0.117), but a marginal positive association was observed in three cohort studies (relative risk (RR) 1.22, 95% CI: 1.00–1.49, I2 = 0.0%, p = 0.995). Particularly, a negative association was observed in North America (OR = 0.70, 95% CI: 0.59–0.83, I2 = 8.9%, p = 0.362). In addition, a positive association was observed in cereal fiber (RR = 1.26, 95% CI: 1.03–1.52, I2 = 0.0%, p = 0.530, 3 cohort studies) and a negative association was observed in vegetable fiber (OR = 0.74, 95% CI: 0.58–0.94, I2 = 0.0%, p = 0.445, 3 case–control studies). In conclusion, negative associations with endometrial cancer risk were observed for higher total dietary fiber intake and higher vegetable fiber intake in the case–control studies. However, results from the cohort studies suggested positive relationships of higher total fiber intake and higher cereal fiber intake with endometrial cancer risk. View Full-Text
Keywords: endometrial cancer; dietary fiber; meta-analysis; systematic review endometrial cancer; dietary fiber; meta-analysis; systematic review
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Chen, K.; Zhao, Q.; Li, X.; Zhao, J.; Li, P.; Lin, S.; Wang, H.; Zang, J.; Xiao, Y.; Xu, W.; Chen, F.; Gao, Y. Dietary Fiber Intake and Endometrial Cancer Risk: A Systematic Review and Meta-Analysis. Nutrients 2018, 10, 945.

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