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Open AccessArticle

Short-Term Daily Intake of Polydextrose Fiber Does Not Shorten Intestinal Transit Time in Constipated Adults: A Randomized Controlled Trial

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Nestlé Research Center, 1000 Lausanne, Switzerland
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Department of Epidemiology, Julius Center for Health Sciences and Primary Care, UMC Utrecht, 3508 GA Utrecht, The Netherlands
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Department of Science, Julius Clinical, 3703 CD Zeist, The Netherlands
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Clinical Development Unit, Nestlé Research Center, 1000 Lausanne, Switzerland
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Department of Nutritional Sciences, King’s College London, London SE1 9NH, UK
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The Centre for Trauma and Surgery and GI Physiology Unit, The Blizard Institute, Barts and the London School of Medicine and Dentistry, Queen Mary University of London, London E1 1BB, UK
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Department of Primary Care, Julius Center for Health Sciences and Primary Care, UMC Utrecht, 3508 GA Utrecht, The Netherlands
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Department of Radiology, Diakonessenhuis Utrecht, 3582 KE Utrecht, The Netherlands
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Author to whom correspondence should be addressed.
Nutrients 2018, 10(7), 920; https://doi.org/10.3390/nu10070920
Received: 26 June 2018 / Revised: 14 July 2018 / Accepted: 17 July 2018 / Published: 19 July 2018
Chronic constipation (CC) remains a common gastrointestinal (GI) disorder that conveys a substantial healthcare burden. Expert guidelines recommend increasing fiber intake, yet the clinical evidence to support this needs strengthening for specific fibers. The aim was to evaluate changes in intestinal transit time and GI symptoms in CC patients who consumed polydextrose. In a randomized, double-blind, placebo-controlled trial, 128 adults with CC received 8 g or 12 g polydextrose, or placebo, daily for 4 weeks. Transit time, as primary outcome, was assessed by radiopaque marker distribution after 2-weeks intervention. Bowel habits, GI symptoms and quality of life (QOL) were assessed by questionnaire, including the Patient-Assessment of Constipation (PAC) Symptoms (SYM), and PAC-QOL. Following 2-weeks intervention, no reduction was seen in transit time in any group and following 2- or 4-weeks intervention, no improvements were seen in stool frequency or consistency in any group. After 2-weeks intervention with 8 g/day polydextrose an improvement was seen in the PAC-SYM rectal score (p = 0.041). After 4-weeks intervention both rectal (p = 0.049) and stool (p = 0.029) scores improved while improvement in the QOL satisfaction score did not reach significance (p = 0.071). Overall, the results suggest that 2-weeks consumption of 8 or 12 g/day polydextrose does not significantly improve physiological measures of gut function in CC adults. Longer term consumption may improve clinical measures, but further studies will be required to substantiate this. View Full-Text
Keywords: constipation; fiber; polydextrose; adult; randomized controlled trial; intestinal transit; intestinal function; patient-reported outcome constipation; fiber; polydextrose; adult; randomized controlled trial; intestinal transit; intestinal function; patient-reported outcome
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Duncan, P.I.; Enters-Weijnen, C.F.; Emami, N.; McLean, P.; Nunes, T.; Beaumont, M.; Crabbe, R.; Whelan, K.; Scott, S.M.; DeWit, N.J.; Weits, T.; Bergonzelli, G.; Grobbee, D.E. Short-Term Daily Intake of Polydextrose Fiber Does Not Shorten Intestinal Transit Time in Constipated Adults: A Randomized Controlled Trial. Nutrients 2018, 10, 920.

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