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Open AccessFeature PaperArticle

Interaction between an ADCY3 Genetic Variant and Two Weight-Lowering Diets Affecting Body Fatness and Body Composition Outcomes Depending on Macronutrient Distribution: A Randomized Trial

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Department of Nutrition, Food Sciences and Physiology, University of Navarra, 31008 Pamplona, Spain
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Centre for Nutrition Research, University of Navarra, 31008 Pamplona, Spain
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Navarra Institute for Health Research (IdiSNA), 31008 Pamplona, Spain
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Biomedical Research Centre Network in Physiopathology of Obesity and Nutrition (CIBERobn), Institute of Health Carlos III, 28029 Madrid, Spain
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Centro Nacional de Biotecnología (CNB-CSIC), 28049 Madrid, Spain
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Biomedical Research Centre Network in Hepatic and Gastrointestinal diseases (CIBERehd), Institute of Health Carlos III, 28029 Madrid, Spain
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Genomic Core Facility, Center for Applied Medical Research (CIMA), University of Navarra, 31008 Pamplona, Spain
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Research Institute of Food & Health Sciences (IMDEA Food), 28049 Madrid, Spain
*
Author to whom correspondence should be addressed.
Nutrients 2018, 10(6), 789; https://doi.org/10.3390/nu10060789
Received: 3 May 2018 / Revised: 6 June 2018 / Accepted: 15 June 2018 / Published: 19 June 2018
(This article belongs to the Special Issue Nutrigenomics)
The adenylate cyclase 3 (ADCY3) gene is involved in the regulation of several metabolic processes including the development and function of adipose tissue. The effects of the ADCY3 rs10182181 genetic variant on changes in body composition depending on the macronutrient distribution intake after 16 weeks of the dietary intervention were tested. The ADCY3 genetic variant was genotyped in 147 overweight or obese subjects, who were randomly assigned to one of the two diets varying in macronutrient content: a moderately-high-protein diet and a low-fat diet. Anthropometric and body composition measurements (DEXA scan) were recorded. Significant interactions between the ADCY3 genotype and dietary intervention on changes in weight, waist circumference, and body composition were found after adjustment for covariates. Thus, in the moderately-high-protein diet group, the G allele was associated with a lower decrease of fat mass, trunk and android fat, and a greater decrease in lean mass. Conversely, in the low-fat diet group carrying the G allele was associated with a greater decrease in trunk, android, gynoid, and visceral fat. Subjects carrying the G allele of the rs10182181 polymorphism may benefit more in terms of weight loss and improvement of body composition measurements when undertaking a hypocaloric low-fat diet as compared to a moderately-high-protein diet. View Full-Text
Keywords: ADCY3; gene–diet interaction; energy restricted diet; body fatness; body composition ADCY3; gene–diet interaction; energy restricted diet; body fatness; body composition
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Goni, L.; Riezu-Boj, J.I.; Milagro, F.I.; Corrales, F.J.; Ortiz, L.; Cuervo, M.; Martínez, J.A. Interaction between an ADCY3 Genetic Variant and Two Weight-Lowering Diets Affecting Body Fatness and Body Composition Outcomes Depending on Macronutrient Distribution: A Randomized Trial. Nutrients 2018, 10, 789.

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