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Serum Magnesium after Kidney Transplantation: A Systematic Review

LUNAM Université, 49180 Angers, France
Université Angers, CHU Angers, Service de Néphrologie-Dialyse-Transplantation, CHU d’Angers, 49933 Angers CEDEX 9, France
CRCINA, INSERM, Université de Nantes, Université d’Angers, LabEx IGO Immunotherapy, Graft, Oncology, 44007 Angers, France
Author to whom correspondence should be addressed.
Nutrients 2018, 10(6), 729;
Received: 25 April 2018 / Revised: 28 May 2018 / Accepted: 31 May 2018 / Published: 6 June 2018
(This article belongs to the Special Issue Magnesium Intake and Human Health)
Magnesium (Mg) status has recently drawn close attention in chronic kidney disease and in kidney transplant recipients. This review aims to evaluate the body of evidence linking hypomagnesemia to clinical consequences in these specific populations. After a brief summary of the main mechanisms involved in Mg regulation and of Mg status in end-stage renal disease, the review focuses on the relationship between hypomagnesemia and cardiovascular risk in kidney transplant recipients. A body of evidence in recent studies points to a negative impact of hypomagnesemia on post-transplant diabetes mellitus (PTDM) and cardiovascular risk, which currently represent the main threat for morbidity and mortality in kidney transplantation. Deleterious biological mechanisms induced by hypomagnesemia are also discussed. While data analysis enables us to conclude that hypomagnesemia is linked to the development of PTDM, studies prospectively evaluating the impact of hypomagnesemia correction after kidney transplantation are still lacking and needed. View Full-Text
Keywords: Magnesium-Kidney; transplantation-New-onset; diabetes after transplantation-cardiovascular risk Magnesium-Kidney; transplantation-New-onset; diabetes after transplantation-cardiovascular risk
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MDPI and ACS Style

Garnier, A.-S.; Duveau, A.; Planchais, M.; Subra, J.-F.; Sayegh, J.; Augusto, J.-F. Serum Magnesium after Kidney Transplantation: A Systematic Review. Nutrients 2018, 10, 729.

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