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Dietary Selenium Intake and Subclinical Hypothyroidism: A Cross-Sectional Analysis of the ELSA-Brasil Study

Department of Nutrition, School of Public Health, University of São Paulo, São Paulo CEP 03178-200, Brazil
Department of Food and Nutrition, School of Nutrition, Federal University of Mato Grosso, Cuiabá CEP 78060-900, Brazil
Clinical and Epidemiological Research Center, University Hospital, University of São Paulo, São Paulo CEP 05508-000, Brazil
Author to whom correspondence should be addressed.
Nutrients 2018, 10(6), 693;
Received: 3 May 2018 / Revised: 21 May 2018 / Accepted: 28 May 2018 / Published: 30 May 2018
Selenium (Se) participates in several enzymatic reactions necessary for regulating the homeostasis of thyroid hormones. We aimed to analyze the association between dietary Se intake and subclinical hypothyroidism. Baseline data from the Longitudinal Study of Adult Health (Estudo Longitudinal de Saúde do Adulto—ELSA-Brasil) in Brazil were analyzed, with a final sample size of 14,283 employees of both sexes aged 35–74 years. Dietary data was collected using a previously validated food frequency questionnaire. Subclinical hypothyroidism was categorized as thyroid-stimulating hormone levels of >4.0 IU/mL and free prohormone thyroxine levels within normal limits, without administering drugs for thyroid disease. A multiple logistic regression model was used to assess the relationship between the presence of subclinical hypothyroidism and tertiles of Se consumption. The prevalence of subclinical hypothyroidism in the study sample was 5.4% (95% confidence interval [CI], 3.8–7.0%). Compared with the first tertile of Se intake, the second (odds ratio [OR], 0.79; 95% CI, 0.65–0.96%) and third (OR, 0.72; 95% CI, 0.58–0.90%) tertiles were inversely associated with subclinical hypothyroidism, however further research is needed to confirm the involvement of Se in subclinical hypothyroidism using more accurate methodologies of dietary assessment and nutritional status to evaluate this relationship. View Full-Text
Keywords: selenium; diet; subclinical hypothyroidism; adults; thyroid selenium; diet; subclinical hypothyroidism; adults; thyroid
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Andrade, G.R.G.; Gorgulho, B.; Lotufo, P.A.; Bensenor, I.M.; Marchioni, D.M. Dietary Selenium Intake and Subclinical Hypothyroidism: A Cross-Sectional Analysis of the ELSA-Brasil Study. Nutrients 2018, 10, 693.

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