Dietary Nutrients and Bioactive Substances Modulate Heat Shock Protein (HSP) Expression: A Review
1
Protein Resources Laboratory, Food and Nutrition Department, Faculty of Food Engineering, University of Campinas (UNICAMP), Campinas 13083-862 São Paulo, Brazil
2
School of Health Sciences, Federal University of Grande Dourados, Dourados 79825-070, Mato Grosso do Sul, Brazil
*
Author to whom correspondence should be addressed.
Nutrients 2018, 10(6), 683; https://doi.org/10.3390/nu10060683
Received: 10 April 2018
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Revised: 21 May 2018
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Accepted: 23 May 2018
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Published: 28 May 2018
Interest in the heat shock proteins (HSPs), as a natural physiological toolkit of living organisms, has ranged from their chaperone function in nascent proteins to the remedial role following cell stress. As part of the defence system, HSPs guarantee cell tolerance against a variety of stressors, including exercise, oxidative stress, hyper and hypothermia, hyper and hypoxia and improper diets. For the past couple of decades, research on functional foods has revealed a number of substances likely to trigger cell protection through mechanisms that involve the induction of HSP expression. This review will summarize the occurrence of the most easily inducible HSPs and describe the effects of dietary proteins, peptides, amino acids, probiotics, high-fat diets and other food-derived substances reported to induce HSP response in animals and humans studies. Future research may clarify the mechanisms and explore the usefulness of this natural alternative of defense and the modulating mechanism of each substance.
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Keywords:
bioactive peptide; obesity; whey protein
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MDPI and ACS Style
Moura, C.S.; Lollo, P.C.B.; Morato, P.N.; Amaya-Farfan, J. Dietary Nutrients and Bioactive Substances Modulate Heat Shock Protein (HSP) Expression: A Review. Nutrients 2018, 10, 683. https://doi.org/10.3390/nu10060683
AMA Style
Moura CS, Lollo PCB, Morato PN, Amaya-Farfan J. Dietary Nutrients and Bioactive Substances Modulate Heat Shock Protein (HSP) Expression: A Review. Nutrients. 2018; 10(6):683. https://doi.org/10.3390/nu10060683
Chicago/Turabian StyleMoura, Carolina S., Pablo C.B. Lollo, Priscila N. Morato, and Jaime Amaya-Farfan. 2018. "Dietary Nutrients and Bioactive Substances Modulate Heat Shock Protein (HSP) Expression: A Review" Nutrients 10, no. 6: 683. https://doi.org/10.3390/nu10060683
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