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Nutrients 2018, 10(6), 659;

A Randomized Study to Compare a Monthly to a Daily Administration of Vitamin D3 Supplementation

Clinical Department, Laboratoires SMB SA, 1080 Brussels, Belgium
Department of Clinical Pharmacology, ATC SA, 4000 Liège, Belgium
Laboratoire d’Explorations fonctionnelles, Hôpital Necker-Enfants malades, Paris 75014, France
Department of Clinical Chemistry, University of Liège, CHU Sart-Tilman, 4000 Liège, Belgium
Author to whom correspondence should be addressed.
Received: 12 April 2018 / Revised: 15 May 2018 / Accepted: 16 May 2018 / Published: 23 May 2018
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We aimed to determine whether a cumulative dose of vitamin D3 produces the same effects on the serum concentration of 25(OH)D3 if it is given daily or monthly. This is a monocentric, two-armed, randomized, interventional, open, and parallel study conducted from November 2016 to March 2017 in Belgium. We randomized 60 subjects with vitamin D deficiency to receive 2000 IU vitamin D3 daily or 50,000 IU monthly. The same cumulative dose of vitamin D3 was given to each treatment group (150,000 IU). The 25(OH)D3 serum concentrations from baseline to day 75 were 14.3 ± 3.7 to 27.8 ± 3.9 ng/mL in the monthly group and 14.1 ± 3.4 to 28.8 ± 5.4 ng/mL in the daily group. The mean change versus the baseline level was significantly different between the groups at day 2, 4, 7, and 14 and no longer different from day 25. One day after the intake of vitamin D3, as expected, serum 25(OH)D3 and 1,25(OH)2D3 increased significantly in the monthly group, whereas they did not change significantly in the daily group. The median time to reach the 20 ng/mL target concentration was significantly different in the two groups, in favor of the monthly regimen (1 day versus 14 days; p = 0.02). In conclusion, a monthly administration of 50,000 IU vitamin D3 provides an effective tool for a rapid normalization of 25(OH)D3 in deficient subjects. A daily administration of the same cumulative dose is similarly effective but takes two weeks longer to reach the desirable level of 20 ng/mL. View Full-Text
Keywords: vitamin D; calcidiol; calcitriol; FGF23; regimen; supplementation vitamin D; calcidiol; calcitriol; FGF23; regimen; supplementation

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De Niet, S.; Coffiner, M.; Da Silva, S.; Jandrain, B.; Souberbielle, J.-C.; Cavalier, E. A Randomized Study to Compare a Monthly to a Daily Administration of Vitamin D3 Supplementation. Nutrients 2018, 10, 659.

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