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Nutrients 2018, 10(5), 574; https://doi.org/10.3390/nu10050574

Relationship of a Special Acidified Milk Protein Drink with Cognitive Performance: A Randomized, Double-Blind, Placebo-Controlled, Crossover Study in Healthy Young Adults

1
R & D Division, Meiji Co., Ltd., Tokyo 192-0919, Japan
2
Research Center for Global Agromedicine, Obihiro University of Agriculture and Veterinary Medicine, Hokkaido 080-8555, Japan
3
Health Care Administration Center, Obihiro University of Agriculture and Veterinary Medicine, Hokkaido 080-8555, Japan
4
Obihiro Dai-ichi Hospital, Hokkaido 080-0014, Japan
5
Graduate School of Food Hygiene, Obihiro University of Agriculture and Veterinary Medicine, Hokkaido 080-8555, Japan
*
Author to whom correspondence should be addressed.
Received: 13 April 2018 / Revised: 28 April 2018 / Accepted: 4 May 2018 / Published: 8 May 2018
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Abstract

A previous in vivo study with rats suggested that a special milk protein drink manufactured using an acidification procedure to suppress the aggregation of milk proteins was absorbed quickly after feeding. We performed a randomized, double-blind, placebo-controlled, repeated-measure crossover study to investigate the short-term effects on cognitive performance in 29 healthy young adult men after they consumed this drink in the morning. After an overnight fast, subjects were tested for performance in the Uchida–Kraepelin serial arithmetic test and the Stroop test as well as for subjective feeling, body temperature, and heart rate variability before and after consumption of either the acidified milk protein drink or an isoenergetic placebo drink. Subjects showed a significant improvement in performance in the Uchida–Kraepelin test, the primary outcome measured, when they consumed the acidified milk protein drink compared with the placebo control condition. In addition, consumption of the acidified milk protein drink, compared with the placebo control, was associated with increases in vagally-mediated heart rate variability indices which, from recent theoretical perspectives, may reflect a higher ability to modulate cognitive and behavioral processes. There was no significant difference in subjective feelings and body temperature between the test drink conditions. These data suggest that consumption of the acidified milk protein drink may improve cognitive performance, with possible involvement of physiological systems that regulate cognition and behavior. View Full-Text
Keywords: milk protein; cognitive performance; heart rate variability; clinical study milk protein; cognitive performance; heart rate variability; clinical study
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Saito, Y.; Murata, N.; Noma, T.; Itoh, H.; Kayano, M.; Nakamura, K.; Urashima, T. Relationship of a Special Acidified Milk Protein Drink with Cognitive Performance: A Randomized, Double-Blind, Placebo-Controlled, Crossover Study in Healthy Young Adults. Nutrients 2018, 10, 574.

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