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Emerging Evidence of Thresholds for Beneficial Effects from Vitamin D Supplementation

School of Population Health, University of Auckland, Private Bag 92019, Auckland 1142, New Zealand
Nutrients 2018, 10(5), 561;
Received: 15 March 2018 / Revised: 29 April 2018 / Accepted: 30 April 2018 / Published: 3 May 2018
(This article belongs to the Special Issue Changing Times for Vitamin D and Health)
Publications from clinical trials of vitamin D supplementation have increased substantially over the last 15 years. Yet, despite the growing number of randomized controlled trials, meta-analyses of these studies have drawn inconsistent conclusions. Many meta-analyses assume that vitamin D is a pharmacological agent, and give scant consideration of it being a nutrient. This limits their potential to detect beneficial effects in participants with vitamin D deficiency. An increasing body of evidence from both observational studies and clinical trials supports the presence of thresholds in vitamin D status below which disease risk increases and vitamin supplementation has beneficial effects. Future supplementation trials which seek to replicate these findings should recruit sufficient numbers of participants with low vitamin D levels, and not give low-dose vitamin D to the placebo group. If the presence of vitamin D thresholds for beneficial effects is confirmed, this would strengthen the need for vitamin D fortification of foods. View Full-Text
Keywords: dose–response; randomized controlled trials; thresholds; vitamin D supplementation dose–response; randomized controlled trials; thresholds; vitamin D supplementation
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Scragg, R. Emerging Evidence of Thresholds for Beneficial Effects from Vitamin D Supplementation. Nutrients 2018, 10, 561.

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