Next Article in Journal
The When, What & How of Measuring Vitamin D Metabolism in Clinical Medicine
Previous Article in Journal
Selenium in Radiation Oncology—15 Years of Experiences in Germany
Article Menu
Issue 4 (April) cover image

Export Article

Open AccessArticle
Nutrients 2018, 10(4), 484; https://doi.org/10.3390/nu10040484

Beneficial Effects of Different Flavonoids on Vascular and Renal Function in L-NAME Hypertensive Rats

1
Departamento de Fisiología, Facultad de Medicina & Instituto Murciano de Investigaciones Biosanitarias, Universidad de Murcia, 30120 Murcia, Spain
2
Departamento de Anatomía Patológica, Facultad de Medicina, IBIMER, ibs.Granada, Universidad de Granada, 18011 Granada, Spain
3
Instituto Universitario de Envejecimiento & Research and Development Department, Nutrafur SA-FRUTAROM Group, 30820 Alcantarilla (Murcia), Spain
*
Author to whom correspondence should be addressed.
Received: 7 March 2018 / Revised: 2 April 2018 / Accepted: 10 April 2018 / Published: 13 April 2018
Full-Text   |   PDF [3564 KB, uploaded 3 May 2018]   |  

Abstract

Background: we have evaluated the antihypertensive effect of several flavonoid extracts in a rat model of arterial hypertension caused by chronic administration (6 weeks) of the nitric oxide synthesis inhibitor, L-NAME. Methods: Sprague Dawley rats received L-NAME alone or L-NAME plus flavonoid-rich vegetal extracts (Lemon, Grapefruit + Bitter Orange, and Cocoa) or purified flavonoids (Apigenin and Diosmin) for 6 weeks. Results: L-NAME treatment resulted in a marked elevation of blood pressure, and treatment with Apigenin, Lemon Extract, and Grapefruit + Bitter Orange extracts significantly reduced the elevated blood pressure of these animals. Apigenin and some of these flavonoids also ameliorated nitric oxide-dependent and -independent aortic vasodilation and elevated nitrite urinary excretion. End-organ abnormalities such as cardiac infarcts, hyaline arteriopathy and fibrinoid necrosis in coronary arteries and aorta were improved by these treatments, reducing the end-organ vascular damage. Conclusions: the flavonoids included in this study, specially apigenin, may be used as functional food ingredients with potential therapeutic benefit in arterial hypertension. View Full-Text
Keywords: flavonoids; nitric oxide; heart; kidney; sodium balance; phenylephrine; acetylcholine flavonoids; nitric oxide; heart; kidney; sodium balance; phenylephrine; acetylcholine
Figures

Figure 1

This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited (CC BY 4.0).

Supplementary material

SciFeed

Share & Cite This Article

MDPI and ACS Style

Paredes, M.D.; Romecín, P.; Atucha, N.M.; O’Valle, F.; Castillo, J.; Ortiz, M.C.; García-Estañ, J. Beneficial Effects of Different Flavonoids on Vascular and Renal Function in L-NAME Hypertensive Rats. Nutrients 2018, 10, 484.

Show more citation formats Show less citations formats

Note that from the first issue of 2016, MDPI journals use article numbers instead of page numbers. See further details here.

Related Articles

Article Metrics

Article Access Statistics

1

Comments

[Return to top]
Nutrients EISSN 2072-6643 Published by MDPI AG, Basel, Switzerland RSS E-Mail Table of Contents Alert
Back to Top