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Omega-3 Fatty Acids and Insulin Resistance: Focus on the Regulation of Mitochondria and Endoplasmic Reticulum Stress

1
Department of Chemistry and Biology, University of Salerno, Via Giovanni Paolo II, 132, Fisciano 84084, Italy
2
Department of Biology, University of Naples Federico II, Complesso Universitario di Monte S.Angelo, Edificio 7, via Cintia 26, 80126 Napoli, Italy
*
Author to whom correspondence should be addressed.
These two authors equally contributed to the work.
Nutrients 2018, 10(3), 350; https://doi.org/10.3390/nu10030350
Received: 8 February 2018 / Revised: 4 March 2018 / Accepted: 12 March 2018 / Published: 14 March 2018
(This article belongs to the Special Issue Nutrients, Bioactives and Insulin Resistance)
Mitochondrial dysfunction and endoplasmic reticulum (ER) stress have been suggested to play a key role in insulin resistance development. Reactive oxygen species (ROS) production and lipid accumulation due to mitochondrial dysfunction seemed to be important mechanisms leading to cellular insulin resistance. Moreover, mitochondria are functionally and structurally linked to ER, which undergoes stress in conditions of chronic overnutrition, activating the unfolded protein response, which in turn activates the principal inflammatory pathways that impair insulin action. Among the nutrients, dietary fats are believed to play key roles in insulin resistance onset. However, not all dietary fats exert the same effects on cellular energy metabolism. Dietary omega 3 polyunsaturated fatty acids (PUFA) have been suggested to counteract insulin resistance development by modulating mitochondrial bioenergetics and ER stress. In the current review, we summarized current knowledge on the role played by mitochondrial and ER stress in inflammation and insulin resistance onset, focusing on the modulation role of omega 3 PUFA on these stress pathways. Understanding the mechanisms by which omega 3 PUFA modulates cellular metabolism and insulin resistance in peripheral tissues may provide additional details on the potential impact of omega 3 PUFA on metabolic function and the management of insulin resistance in humans. View Full-Text
Keywords: mitochondrial dysfunction; mitofusin; inflammasome; MAM; EPA; DHA; fish oil; oxidative stress mitochondrial dysfunction; mitofusin; inflammasome; MAM; EPA; DHA; fish oil; oxidative stress
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Lepretti, M.; Martucciello, S.; Burgos Aceves, M.A.; Putti, R.; Lionetti, L. Omega-3 Fatty Acids and Insulin Resistance: Focus on the Regulation of Mitochondria and Endoplasmic Reticulum Stress. Nutrients 2018, 10, 350.

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