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Article

Methyl-Donor and Cofactor Nutrient Intakes in the First 2–3 Years and Global DNA Methylation at Age 4: A Prospective Cohort Study

by
Rachael M. Taylor
1,2,3,*,
Roger Smith
1,2,3,
Clare E. Collins
1,2,3,4,5,
David Mossman
3,6,
Michelle W. Wong-Brown
3,7,
Eng-Cheng Chan
2,3,
Tiffany-Jane Evans
3,8,
John R. Attia
2,3,8,
Tenele Smith
1,2,3,
Trent Butler
1,2,3 and
Alexis J. Hure
2,3,9
1
Priority Research Centre for Reproductive Science, University of Newcastle, Callaghan, NSW 2308, Australia
2
Faculty of Health and Medicine, School of Medicine and Public Health, University of Newcastle, Callaghan, NSW 2308, Australia
3
Hunter Medical Research Institute, 1 Kookaburra Circuit, New Lambton Heights, NSW 2305, Australia
4
Faculty of Health and Medicine, School of Health Sciences, University of Newcastle, Callaghan, NSW 2308, Australia
5
Priority Research Centre in Physical Activity and Nutrition, University of Newcastle, Callaghan, NSW 2308, Australia
6
Department of Molecular Medicine, NSW Health Pathology, John Hunter Hospital, New Lambton Heights, NSW 2305, Australia
7
Faculty of Health, School of Biomedical Sciences and Pharmacy, University of Newcastle, Callaghan, NSW 2308, Australia
8
Clinical Research Design IT and Statistical Support (CReDITSS) Unit, Hunter Medical Research Institute, 1 Kookaburra Circuit, New Lambton Heights, NSW 2305, Australia
9
Priority Research Centre for Generational, Health and Ageing, University of Newcastle, Callaghan, NSW 2308, Australia
*
Author to whom correspondence should be addressed.
Nutrients 2018, 10(3), 273; https://doi.org/10.3390/nu10030273
Submission received: 7 December 2017 / Revised: 13 February 2018 / Accepted: 13 February 2018 / Published: 27 February 2018
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Abstract

Background: During the early postnatal period, the impact of nutrition on DNA methylation has not been well studied in humans. The aim was to quantify the relationship between one-carbon metabolism nutrient intake during the first three years of life and global DNA methylation levels at four years. Design: Childhood dietary intake was assessed using infant feeding questionnaires, food frequency questionnaires, 4-day weighed food records and 24-h food records. The dietary records were used to estimate the intake of methionine, folate, vitamins B2, B6 and B12 and choline. The accumulative nutrient intake specific rank from three months to three years of age was used for analysis. Global DNA methylation (%5-methyl cytosines (%5-mC)) was measured in buccal cells at four years of age, using an enzyme-linked immunosorbent assay (ELISA) commercial kit. Linear regression models were used to quantify the statistical relationships. Results: Data were collected from 73 children recruited from the Women and their Children’s Health (WATCH) study. No association was found between one-carbon metabolism nutrient intake and global DNA methylation levels (P > 0.05). Global DNA methylation levels in males were significantly higher than in females (median %5-mC: 1.82 vs. 1.03, males and females respectively, (P < 0.05)). Conclusion: No association was found between the intake of one-carbon metabolism nutrients during the early postnatal period and global DNA methylation levels at age four years. Higher global DNA methylation levels in males warrants further investigation.
Keywords: child diet; global DNA methylation; nutrition; one-carbon metabolism; postnatal child diet; global DNA methylation; nutrition; one-carbon metabolism; postnatal

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MDPI and ACS Style

Taylor, R.M.; Smith, R.; Collins, C.E.; Mossman, D.; Wong-Brown, M.W.; Chan, E.-C.; Evans, T.-J.; Attia, J.R.; Smith, T.; Butler, T.; et al. Methyl-Donor and Cofactor Nutrient Intakes in the First 2–3 Years and Global DNA Methylation at Age 4: A Prospective Cohort Study. Nutrients 2018, 10, 273. https://doi.org/10.3390/nu10030273

AMA Style

Taylor RM, Smith R, Collins CE, Mossman D, Wong-Brown MW, Chan E-C, Evans T-J, Attia JR, Smith T, Butler T, et al. Methyl-Donor and Cofactor Nutrient Intakes in the First 2–3 Years and Global DNA Methylation at Age 4: A Prospective Cohort Study. Nutrients. 2018; 10(3):273. https://doi.org/10.3390/nu10030273

Chicago/Turabian Style

Taylor, Rachael M., Roger Smith, Clare E. Collins, David Mossman, Michelle W. Wong-Brown, Eng-Cheng Chan, Tiffany-Jane Evans, John R. Attia, Tenele Smith, Trent Butler, and et al. 2018. "Methyl-Donor and Cofactor Nutrient Intakes in the First 2–3 Years and Global DNA Methylation at Age 4: A Prospective Cohort Study" Nutrients 10, no. 3: 273. https://doi.org/10.3390/nu10030273

APA Style

Taylor, R. M., Smith, R., Collins, C. E., Mossman, D., Wong-Brown, M. W., Chan, E.-C., Evans, T.-J., Attia, J. R., Smith, T., Butler, T., & Hure, A. J. (2018). Methyl-Donor and Cofactor Nutrient Intakes in the First 2–3 Years and Global DNA Methylation at Age 4: A Prospective Cohort Study. Nutrients, 10(3), 273. https://doi.org/10.3390/nu10030273

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