Next Article in Journal
Claimed Effects, Outcome Variables and Methods of Measurement for Health Claims on Foods Related to Vision Proposed Under Regulation (EC) 1924/2006
Previous Article in Journal
Effects of an Acute Exercise Bout on Serum Hepcidin Levels
Open AccessArticle

Changes in the Anti-Allergic Activities of Sesame by Bioconversion

1
Department of Food Science and Biotechnology, Kangwon National University, Chuncheon 24341, Korea
2
STR Biotech Company, LTD., Chuncheon 24232, Korea
3
Korea Food Research Institute, Wanju-gun, Jeollabuk-do 55365, Korea
4
Department of Nutrition, University of Massachusetts Amherst, Amherst, MA 01003, USA
*
Authors to whom correspondence should be addressed.
These authors contributed equally to this work.
Nutrients 2018, 10(2), 210; https://doi.org/10.3390/nu10020210
Received: 18 December 2017 / Revised: 12 February 2018 / Accepted: 13 February 2018 / Published: 14 February 2018
Sesame is an important oilseed crop, which has been used as a traditional health food to ameliorate the prevention of various diseases. We evaluated the changes in the anti-allergic activities of sesame by bioconversion. SDS-PAGE of non-fermented sesame proteins showed major allergen bands, while that of fermented sesame showed only a few protein bands. Additionally, we investigated the effectiveness of fermented sesame by bioconversion in tumor necrosis factor-α (TNF-α)- and interferon-γ (IFN-γ)-induced HaCaT cells. In HaCaT cells, fermented sesame inhibited the mRNA expression of interleukin-6 (IL-6) and interleukin-1β (IL-1β), thymus and macrophage-derived chemokine (MDC/CCL22), activation-regulated chemokine (TARC/CCL17), and intercellular adhesion molecule-1 (ICAM-1). Moreover, fermented sesame inhibited the activation of nuclear factor-κB (NF-κB) and signal transducer and activator of transcription 1 (STAT1). Fermented sesame exerts anti-allergic effects by suppressing the expression of chemokines and cytokines via blockade of NF-κB and STAT1 activation. View Full-Text
Keywords: atopic dermatitis; bioconversion; Sesamum indicum L.; skin inflammation; anti-allergic atopic dermatitis; bioconversion; Sesamum indicum L.; skin inflammation; anti-allergic
Show Figures

Figure 1

MDPI and ACS Style

Jung, T.-D.; Choi, S.-I.; Choi, S.-H.; Cho, B.-Y.; Sim, W.-S.; Han-Xionggao; Lee, S.J.; Park, S.J.; Kim, D.-B.; Kim, Y.-C.; Lee, J.-H.; Lee, O.-H. Changes in the Anti-Allergic Activities of Sesame by Bioconversion. Nutrients 2018, 10, 210.

Show more citation formats Show less citations formats
Note that from the first issue of 2016, MDPI journals use article numbers instead of page numbers. See further details here.

Article Access Map by Country/Region

1
Back to TopTop