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Changes in the Anti-Allergic Activities of Sesame by Bioconversion

Department of Food Science and Biotechnology, Kangwon National University, Chuncheon 24341, Korea
STR Biotech Company, LTD., Chuncheon 24232, Korea
Korea Food Research Institute, Wanju-gun, Jeollabuk-do 55365, Korea
Department of Nutrition, University of Massachusetts Amherst, Amherst, MA 01003, USA
Authors to whom correspondence should be addressed.
These authors contributed equally to this work.
Nutrients 2018, 10(2), 210;
Received: 18 December 2017 / Revised: 12 February 2018 / Accepted: 13 February 2018 / Published: 14 February 2018
Sesame is an important oilseed crop, which has been used as a traditional health food to ameliorate the prevention of various diseases. We evaluated the changes in the anti-allergic activities of sesame by bioconversion. SDS-PAGE of non-fermented sesame proteins showed major allergen bands, while that of fermented sesame showed only a few protein bands. Additionally, we investigated the effectiveness of fermented sesame by bioconversion in tumor necrosis factor-α (TNF-α)- and interferon-γ (IFN-γ)-induced HaCaT cells. In HaCaT cells, fermented sesame inhibited the mRNA expression of interleukin-6 (IL-6) and interleukin-1β (IL-1β), thymus and macrophage-derived chemokine (MDC/CCL22), activation-regulated chemokine (TARC/CCL17), and intercellular adhesion molecule-1 (ICAM-1). Moreover, fermented sesame inhibited the activation of nuclear factor-κB (NF-κB) and signal transducer and activator of transcription 1 (STAT1). Fermented sesame exerts anti-allergic effects by suppressing the expression of chemokines and cytokines via blockade of NF-κB and STAT1 activation. View Full-Text
Keywords: atopic dermatitis; bioconversion; Sesamum indicum L.; skin inflammation; anti-allergic atopic dermatitis; bioconversion; Sesamum indicum L.; skin inflammation; anti-allergic
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Jung, T.-D.; Choi, S.-I.; Choi, S.-H.; Cho, B.-Y.; Sim, W.-S.; Han-Xionggao; Lee, S.J.; Park, S.J.; Kim, D.-B.; Kim, Y.-C.; Lee, J.-H.; Lee, O.-H. Changes in the Anti-Allergic Activities of Sesame by Bioconversion. Nutrients 2018, 10, 210.

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