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Effects of an Acute Exercise Bout on Serum Hepcidin Levels

College of Health Sciences, Alfonso X El Sabio University, 29691 Madrid, Spain
College of Health Sciences, Isabel I University, 09004 Burgos, Spain
Department of Sports, Faculty of Sports Sciences, University Pablo Olavide, 4103 Sevilla, Spain
Department of Physical Education and Sports, Faculty of Educational Sciences, University of Seville, 41013 Sevilla, Spain
NutriScience España, 14010 Córdoba, Spain
University Study Center Cardenal Spinola, CEU San Pablo University, 41930 Sevilla, Spain
School of Physiotherapy, School of Health Sciences, Francisco de Vitoria, 28223 Pozuelo, Spain
Department of Medicine and Medical Specialties and Department of Biomedical Sciences, Faculty of Medicine and Health Sciences, University of Alcalá, 28871 Madrid, Spain
Author to whom correspondence should be addressed.
Nutrients 2018, 10(2), 209;
Received: 26 December 2017 / Revised: 30 January 2018 / Accepted: 11 February 2018 / Published: 14 February 2018
(This article belongs to the Special Issue Fe Deficiency, Dietary Bioavailbility and Absorption)
Iron deficiency is a frequent and multifactorial disorder in the career of athletes, particularly in females. Exercise-induced disturbances in iron homeostasis produce deleterious effects on performance and adaptation to training; thus, the identification of strategies that restore or maintain iron homeostasis in athletes is required. Hepcidin is a liver-derived hormone that degrades the ferroportin transport channel, thus reducing the ability of macrophages to recycle damaged iron, and decreasing iron availability. Although it has been suggested that the circulating fraction of hepcidin increases during early post-exercise recovery (~3 h), it remains unknown how an acute exercise bout may modify the circulating expression of hepcidin. Therefore, the current review aims to determine the post-exercise expression of serum hepcidin in response to a single session of exercise. The review was carried out in the Dialnet, Elsevier, Medline, Pubmed, Scielo and SPORTDiscus databases, using hepcidin (and “exercise” or “sport” or “physical activity”) as a strategy of search. A total of 19 articles were included in the review after the application of the inclusion/exclusion criteria. This search found that a single session of endurance exercise (intervallic or continuous) at moderate or vigorous intensity (60–90% VO2peak) stimulates an increase in the circulating levels of hepcidin between 0 h and 6 h after the end of the exercise bout, peaking at ~3 h post-exercise. The magnitude of the response of hepcidin to exercise seems to be dependent on the pre-exercise status of iron (ferritin) and inflammation (IL-6). Moreover, oxygen disturbances and the activation of a hypoxia-induced factor during or after exercise may stimulate a reduction of hepcidin expression. Meanwhile, cranberry flavonoids supplementation promotes an anti-oxidant effect that may facilitate the post-exercise expression of hepcidin. Further studies are required to explore the effect of resistance exercise on hepcidin expression. View Full-Text
Keywords: iron metabolism; anemia; endurance; exercise; sport performance iron metabolism; anemia; endurance; exercise; sport performance
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MDPI and ACS Style

Domínguez, R.; Sánchez-Oliver, A.J.; Mata-Ordoñez, F.; Feria-Madueño, A.; Grimaldi-Puyana, M.; López-Samanes, Á.; Pérez-López, A. Effects of an Acute Exercise Bout on Serum Hepcidin Levels. Nutrients 2018, 10, 209.

AMA Style

Domínguez R, Sánchez-Oliver AJ, Mata-Ordoñez F, Feria-Madueño A, Grimaldi-Puyana M, López-Samanes Á, Pérez-López A. Effects of an Acute Exercise Bout on Serum Hepcidin Levels. Nutrients. 2018; 10(2):209.

Chicago/Turabian Style

Domínguez, Raúl, Antonio J. Sánchez-Oliver, Fernando Mata-Ordoñez, Adrián Feria-Madueño, Moisés Grimaldi-Puyana, Álvaro López-Samanes, and Alberto Pérez-López. 2018. "Effects of an Acute Exercise Bout on Serum Hepcidin Levels" Nutrients 10, no. 2: 209.

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