Nesfatin-130-59 Injected Intracerebroventricularly Increases Anxiety, Depression-Like Behavior, and Anhedonia in Normal Weight Rats
AbstractNesfatin-1 is a well-established anorexigenic peptide. Recent studies indicated an association between nesfatin-1 and anxiety/depression-like behavior. However, it is unclear whether this effect is retained in obesity. The aim was to investigate the effect of nesfatin-130-59—the active core of nesfatin-1—on anxiety and depression-like behavior in normal weight (NW) and diet-induced (DIO) obese rats. Male rats were intracerebroventricularly (ICV) cannulated and received nesfatin-130-59 (0.1, 0.3, or 0.9 nmol/rat) or vehicle 30 min before testing. Nesfatin-130-59 at a dose of 0.3 nmol reduced sucrose consumption in the sucrose preference test in NW rats compared to vehicle (–33%, p < 0.05), indicating depression-like/anhedonic behavior. This dose was used for all following experiments. Nesfatin-130-59 also reduced cookie intake during the novelty-induced hypophagia test (−62%, p < 0.05). Moreover, nesfatin-130-59 reduced the number of entries into the center zone in the open field test (−45%, p < 0.01) and the visits of open arms in the elevated zero maze test (−39%, p < 0.01) in NW rats indicating anxiety. Interestingly, DIO rats showed no behavioral alterations after the injection of nesfatin-130-59 (p > 0.05). These results indicate an implication of nesfatin-130-59 in the mediation of anxiety and depression-like behavior/anhedonia under normal weight conditions, while in DIO rats, a desensitization might occur. View Full-Text
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Kühne, S.G.; Schalla, M.A.; Friedrich, T.; Kobelt, P.; Goebel-Stengel, M.; Long, M.; Rivalan, M.; Winter, Y.; Rose, M.; Stengel, A. Nesfatin-130-59 Injected Intracerebroventricularly Increases Anxiety, Depression-Like Behavior, and Anhedonia in Normal Weight Rats. Nutrients 2018, 10, 1889.
Kühne SG, Schalla MA, Friedrich T, Kobelt P, Goebel-Stengel M, Long M, Rivalan M, Winter Y, Rose M, Stengel A. Nesfatin-130-59 Injected Intracerebroventricularly Increases Anxiety, Depression-Like Behavior, and Anhedonia in Normal Weight Rats. Nutrients. 2018; 10(12):1889.Chicago/Turabian Style
Kühne, Stephanie G.; Schalla, Martha A.; Friedrich, Tiemo; Kobelt, Peter; Goebel-Stengel, Miriam; Long, Melissa; Rivalan, Marion; Winter, York; Rose, Matthias; Stengel, Andreas. 2018. "Nesfatin-130-59 Injected Intracerebroventricularly Increases Anxiety, Depression-Like Behavior, and Anhedonia in Normal Weight Rats." Nutrients 10, no. 12: 1889.
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