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Circulating Linoleic Acid is Associated with Improved Glucose Tolerance in Women after Gestational Diabetes

1
Institute of Neuroscience and Physiology, Sahlgrenska Academy, University of Gothenburg, 405 30 Gothenburg, Sweden
2
Division of Food and Nutrition Science, Department of Biology and Biological Engineering, Chalmers University of Technology, 412 96 Gothenburg, Sweden
*
Author to whom correspondence should be addressed.
Nutrients 2018, 10(11), 1629; https://doi.org/10.3390/nu10111629
Received: 26 September 2018 / Revised: 23 October 2018 / Accepted: 24 October 2018 / Published: 2 November 2018
Women with previously diagnosed gestational diabetes mellitus (GDM) are at increased risk of type-2-diabetes mellitus (T2D). We aimed to establish links between glucose tolerance (GT) and serum fatty acid (FA) profile in the transition from GDM to T2D. Six years after GDM, 221 women were grouped as having normal GT (NGT), impaired GT (IGT), or T2D based on oral GT test results. Fasting serum FAs were profiled, anthropometric measures taken, and dietary intake determined. Linoleic acid (LA) was significantly higher in NGT women (p < 0.001) compared with IGT and T2D, and emerged as a strong predictor of low glucose and insulin levels, independently of BMI. Self-reported vegetable oil consumption correlated with LA serum levels and glucose levels. Delta-6-, delta-9-, and stearoyl-CoA-desaturase activities were associated with decreased GT, and delta-5-desaturase activities with increased GT. In a subgroup of women at high risk of diabetes, low LA and high palmitic acid levels were seen in those that developed T2D, with no differences in other FAs or metabolic measurements. Results suggest that proportions of LA and palmitic acid are of particular interest in the transition from GDM to T2D. Interconversions between individual FAs regulated by desaturases appear to be relevant to glucose metabolism. View Full-Text
Keywords: gestational diabetes mellitus; serum fatty acids; linoleic acid; glucose tolerance gestational diabetes mellitus; serum fatty acids; linoleic acid; glucose tolerance
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MDPI and ACS Style

Andersson-Hall, U.; Carlsson, N.-G.; Sandberg, A.-S.; Holmäng, A. Circulating Linoleic Acid is Associated with Improved Glucose Tolerance in Women after Gestational Diabetes. Nutrients 2018, 10, 1629. https://doi.org/10.3390/nu10111629

AMA Style

Andersson-Hall U, Carlsson N-G, Sandberg A-S, Holmäng A. Circulating Linoleic Acid is Associated with Improved Glucose Tolerance in Women after Gestational Diabetes. Nutrients. 2018; 10(11):1629. https://doi.org/10.3390/nu10111629

Chicago/Turabian Style

Andersson-Hall, Ulrika, Nils-Gunnar Carlsson, Ann-Sofie Sandberg, and Agneta Holmäng. 2018. "Circulating Linoleic Acid is Associated with Improved Glucose Tolerance in Women after Gestational Diabetes" Nutrients 10, no. 11: 1629. https://doi.org/10.3390/nu10111629

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