Microbial and Nutritional Programming—The Importance of the Microbiome and Early Exposure to Potential Food Allergens in the Development of Allergies
Immunology Laboratory, Department of Pathology, The Children’s Memorial Health Institute, Aleja Dzieci Polskich 20, 04-730 Warsaw, Poland
Nutrients 2018, 10(10), 1541; https://doi.org/10.3390/nu10101541
Received: 30 September 2018
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Revised: 15 October 2018
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Accepted: 16 October 2018
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Published: 18 October 2018
(This article belongs to the Special Issue Probiotics and Prebiotics in Pediatrics)
The “microbiota hypothesis” ties the increase in allergy rates observed in highly developed countries over the last decades to disturbances in the gut microbiota. Gut microbiota formation depends on a number of factors and occurs over approximately 1000 days of life, including the prenatal period. During this period the microbiota helps establish the functional immune phenotype, including immune tolerance. The development of immune tolerance depends also on early exposure to potential food allergens, a process referred to as nutritional programming. This article elaborates on the concepts of microbial and nutritional programming and their role in the primary prevention of allergy.
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Keywords:
microbiome; intestinal microbiota; microbial programming; nutritional programming; allergy; prevention
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MDPI and ACS Style
Cukrowska, B. Microbial and Nutritional Programming—The Importance of the Microbiome and Early Exposure to Potential Food Allergens in the Development of Allergies. Nutrients 2018, 10, 1541. https://doi.org/10.3390/nu10101541
AMA Style
Cukrowska B. Microbial and Nutritional Programming—The Importance of the Microbiome and Early Exposure to Potential Food Allergens in the Development of Allergies. Nutrients. 2018; 10(10):1541. https://doi.org/10.3390/nu10101541
Chicago/Turabian StyleCukrowska, Bożena. 2018. "Microbial and Nutritional Programming—The Importance of the Microbiome and Early Exposure to Potential Food Allergens in the Development of Allergies" Nutrients 10, no. 10: 1541. https://doi.org/10.3390/nu10101541
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