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Open AccessFeature PaperArticle

Altered Dairy Protein Intake Does Not Alter Circulatory Branched Chain Amino Acids in Healthy Adults: A Randomized Controlled Trial

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Liggins Institute, The University of Auckland, 85 Park Road, Grafton, Private Bag 92019, Auckland 1023, New Zealand
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Department of Food Technology and Nutritional Science, Mawlana Bhashani Science and Technology University, Tangail 1902, Bangladesh
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Riddet Institute, Palmerston North 4442, New Zealand
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Food Nutrition & Health Team, AgResearch Limited, Private Bag 11008, Palmerston North 4442, New Zealand
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The High-Value Nutrition National Science Challenge, Auckland-1023, New Zealand
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School of Medicine, Faculty of Medical and Health Sciences, The University of Auckland, 85 Park Road, Grafton, Private Bag 92019, Auckland 1023, New Zealand
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Green Lane Cardiovascular Service, Auckland City Hospital, Auckland 1030, New Zealand
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Food & Bio-Based Products Group, AgResearch Limited, Private Bag 11008, Palmerston North 4442, New Zealand
*
Author to whom correspondence should be addressed.
Nutrients 2018, 10(10), 1510; https://doi.org/10.3390/nu10101510
Received: 14 August 2018 / Revised: 8 October 2018 / Accepted: 12 October 2018 / Published: 15 October 2018
Dairy, as a major component of a high protein diet, is a critical dietary source of branched chain amino acids (BCAA), which are biomarkers of health and diseases. While BCAA are known to be key stimulators of protein synthesis, elevated circulatory BCAA is an independent risk factor for type 2 diabetes mellitus. This study examined the impact of altered dairy intake on plasma BCAA and their potential relationship to insulin sensitivity. Healthy adults (n = 102) were randomized to receive dietary advice to reduce, maintain, or increase habitual dairy intake for 1 month. Food intake was recorded with food frequency questionnaires. Self-reported protein intake from dairy was reported to be reduced (−14.6 ± 3.0 g/day), maintained (−4.0 ± 2.0 g/day) or increased (+13.8 ± 4.1 g/day) according to group allocation. No significant alterations in circulating free amino acids (AA), including BCAA, were measured. Insulin sensitivity, as assessed by homeostatic model assessment-insulin resistance (HOMA-IR), was also unaltered. A significant change in dairy protein intake showed no significant effect on fasting circulatory BCAA and insulin sensitivity in healthy populations. View Full-Text
Keywords: amino acids; protein; insulin sensitivity; randomized controlled trial amino acids; protein; insulin sensitivity; randomized controlled trial
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Prodhan, U.K.; Milan, A.M.; Thorstensen, E.B.; Barnett, M.P.G.; Stewart, R.A.H.; Benatar, J.R.; Cameron-Smith, D. Altered Dairy Protein Intake Does Not Alter Circulatory Branched Chain Amino Acids in Healthy Adults: A Randomized Controlled Trial. Nutrients 2018, 10, 1510.

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