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Nutrients 2018, 10(10), 1488; https://doi.org/10.3390/nu10101488

Family History of Premature Coronary Artery Disease (P-CAD)—A Non-Modifiable Risk Factor? Dietary Patterns of Young Healthy Offspring of P-CAD Patients: A Case-Control Study (MAGNETIC Project)

1
2nd Department of Cardiology and Angiology, Silesian Center for Heart Diseases, Marii Skłodowskiej-Curie 9, 41-800 Zabrze, Poland
2
Department of Pharmacology, School of Medicine with the Division of Dentistry in Zabrze, Jordana 38, 41-808 Zabrze, Medical University of Silesia, 40-055 Katowice, Poland
3
Institute of Occupational Medicine and Environmental Health, Kościelna 13, 40-001 Sosnowiec, Poland
4
Department of Human Nutrition, Faculty of Food Science, University of Warmia and Mazury in Olsztyn, Sloneczna 45f, 10-718 Olsztyn, Poland
5
Genomics Laboratory, Kardio-Med Silesia Science and Technology Park, Marii Skłodowskiej-Curie 10C, 41-800 Zabrze, Poland
6
3rd Department of Cardiology, School of Medicine with the Division of Dentistry in Zabrze, Medical University of Silesia in Katowice, Silesian Center for Heart Diseases, Marii Skłodowskiej-Curie 9, 41-800 Zabrze, Poland
7
Department of Medical and Molecular Biology, School of Medicine with the Division of Dentistry in Zabrze, Jordana 19, 41-808 Zabrze, Medical University of Silesia, 40-055 Katowice, Poland
8
Department of Environmental Medicine and Epidemiology, School of Medicine with the Division of Dentistry in Zabrze, Jordana 19, 41-808 Zabrze, Medical University of Silesia, 40-055 Katowice, Poland
9
Students’ Scientific Society, 3rd Department of Cardiology, School of Medicine with the Division of Dentistry in Zabrze, Medical University of Silesia in Katowice, Silesian Center for Heart Diseases, Marii Skłodowskiej-Curie 9, 41-800 Zabrze, Poland
10
Department of Cardiology, University Hospital in Opole, Faculty of Natural Sciences and Technology, Institute of Medicine, University of Opole, W. Witosa 26, 45-401 Opole, Poland
*
Author to whom correspondence should be addressed.
Received: 22 August 2018 / Revised: 20 September 2018 / Accepted: 30 September 2018 / Published: 12 October 2018
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Abstract

Dietary habits of healthy offspring with a positive family history of premature coronary artery disease (P-CAD) have not been studied so far. The aim of this study was twofold: (1) to identify dietary patterns in a sample of young healthy adults with (cases) and without (controls) family history of P-CAD, and (2) to study the association between dietary patterns and family history of P-CAD. The data came from the MAGNETIC case-control study. The participants were healthy adults aged 18–35 years old, with (n = 351) and without a family history of P-CAD (n = 338). Dietary data were collected with food frequency questionnaire FFQ-6. Dietary patterns (DP) were derived using principal component analysis (PCA). The associations between the adherence to DPs and family history of P-CAD were investigated using logistic regression. Two models were created: crude and adjusted for age, sex, smoking status, place of residence, financial situation, education, and physical activity at leisure time. Three DPs were identified: ‘prudent’, ‘westernized traditional’ and ‘dairy, breakfast cereals, and treats’. In both crude and adjusted models, subjects with family history of P-CAD showed higher adherence by 31% and 25% to ‘westernized traditional’ DP (odds ratio (OR) 1.31, 95% confidence interval (95% CI): 1.12–1.53; p < 0.005; per 1 unit of standard deviation (SD) of DP score and adjOR 1.25, 95% CI: 1.06–1.48; p = 0.007; per 1 unit of SD of DP score, respectively). Young healthy adults with family history of P-CAD present unfavorable dietary patterns and are potentially a target group for CAD primary prevention programs. View Full-Text
Keywords: dietary patterns; family history; FFQ-6; PCA; premature coronary artery disease; P-CAD dietary patterns; family history; FFQ-6; PCA; premature coronary artery disease; P-CAD
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Osadnik, T.; Pawlas, N.; Lonnie, M.; Osadnik, K.; Lejawa, M.; Wądołowska, L.; Bujak, K.; Fronczek, M.; Reguła, R.; Gawlita, M.; Strzelczyk, J.K.; Góral, M.; Gierlotka, M.; Poloński, L.; Gąsior, M. Family History of Premature Coronary Artery Disease (P-CAD)—A Non-Modifiable Risk Factor? Dietary Patterns of Young Healthy Offspring of P-CAD Patients: A Case-Control Study (MAGNETIC Project). Nutrients 2018, 10, 1488.

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