Fish Intake, Circulating Mercury and Mortality in Renal Transplant Recipients
AbstractMarine-derived omega-3 polyunsaturated fatty acids (n-3 PUFAs) are inversely associated with cardiovascular and all-cause mortality in renal transplant recipients (RTRs). Recommendations to increase marine-derived n-3 PUFAs by increasing fish intake may have a drawback in concomitant stimulation of mercury intake, which could lead to higher circulating mercury concentrations and mitigation of otherwise beneficial effects of n-3 PUFAs. We aimed to monitor circulating mercury concentrations, and to prospectively evaluate whether it counteracts the potential association between fish intake and cardiovascular and all-cause mortality in a cohort of RTRs (n = 604, 53 ± 13 years-old, 57% men) with long-term follow-up (median of 5.4 years; 121 deaths). Circulating mercury concentration (median 0.30 (IQR 0.14–0.63) µg/L) positively associated with fish intake (std. β = 0.21, p < 0.001). Multivariable-adjusted Cox-proportional hazards regression analyses showed that prior to, and after additional adjustment for circulating mercury concentrations, fish intake was inversely associated with both cardiovascular (HR 0.75, 95% CI 0.58–0.96; and, HR 0.75, 95% CI 0.58–0.97, respectively) and all-cause mortality (HR 0.84, 95% CI 0.72–0.97; and, HR 0.86, 95% CI 0.74–0.99, respectively). Secondary analyses accounting for marine-derived n-3 PUFAs intake revealed associations of similar magnitude. In conclusion, we found no evidence of a counteracting effect conferred by circulating mercury concentrations on the associations between fish and marine-derived n-3 PUFAs intake and the risks of cardiovascular and all-cause mortality in RTRs. View Full-Text
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Sotomayor, C.G.; Gomes-Neto, A.W.; Gans, R.O.B.; de Borst, M.H.; Berger, S.P.; Rodrigo, R.; Navis, G.J.; Touw, D.J.; Bakker, S.J.L. Fish Intake, Circulating Mercury and Mortality in Renal Transplant Recipients. Nutrients 2018, 10, 1419.
Sotomayor CG, Gomes-Neto AW, Gans ROB, de Borst MH, Berger SP, Rodrigo R, Navis GJ, Touw DJ, Bakker SJL. Fish Intake, Circulating Mercury and Mortality in Renal Transplant Recipients. Nutrients. 2018; 10(10):1419.Chicago/Turabian Style
Sotomayor, Camilo G.; Gomes-Neto, António W.; Gans, Rijk O.B.; de Borst, Martin H.; Berger, Stefan P.; Rodrigo, Ramón; Navis, Gerjan J.; Touw, Daan J.; Bakker, Stephan J.L. 2018. "Fish Intake, Circulating Mercury and Mortality in Renal Transplant Recipients." Nutrients 10, no. 10: 1419.
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