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A Water-Soluble Extract from Actinidia arguta Ameliorates Psoriasis-Like Skin Inflammation in Mice by Inhibition of Neutrophil Infiltration

1
School of Biological Sciences, Seoul National University, Seoul 151-742, Korea
2
ViroMed Co. Ltd., Building 203, Seoul National University, Seoul 151-742, Korea
*
Author to whom correspondence should be addressed.
Nutrients 2018, 10(10), 1399; https://doi.org/10.3390/nu10101399
Received: 26 July 2018 / Revised: 12 September 2018 / Accepted: 28 September 2018 / Published: 2 October 2018
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Abstract

Psoriasis is a chronic inflammatory disease with complex etiology involving multiple factors. Current treatment methods are highly limited and there is a strong need for the development of safer and efficacious agents. We have previously shown that a water-soluble extract derived from hardy kiwifruit Actinidia arguta, called PG102, shows potent anti-inflammatory effects. Based on its reported biological activities, the effects of PG102 were examined on imiquimod-induced psoriasis-like skin inflammation. Our results showed that topical application of PG102 ameliorates clinical symptoms of psoriasis, reducing skin thickness and Interleukin (IL)-17A level in draining lymph nodes without causing any adverse effects. Treatment with PG102 on cytokine-stimulated HaCaT cells suppressed hyperproliferation and downregulated the expression of various chemokines and antimicrobial peptides known to induce neutrophil infiltration. These anti-inflammatory activities of PG102 were mediated via inhibition of NF-κB and signal transducer of activation (STAT) signaling. We also found decreased neutrophil chemotaxis both in vitro and in vivo. Taken together, PG102 has potential as a safe and effective reagent for the treatment of psoriasis. View Full-Text
Keywords: Actinidia arguta; PG102; psoriasis; keratinocyte; neutrophil Actinidia arguta; PG102; psoriasis; keratinocyte; neutrophil
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Kim, H.-K.; Bae, M.J.; Lim, S.; Lee, W.; Kim, S. A Water-Soluble Extract from Actinidia arguta Ameliorates Psoriasis-Like Skin Inflammation in Mice by Inhibition of Neutrophil Infiltration. Nutrients 2018, 10, 1399.

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