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Serum 25-Hydroxyvitamin D and Diet Mediates Vaso-Occlusive Related Hospitalizations in Sickle-Cell Disease Patients

1
Department of Global Environmental Health Sciences, Tulane University School of Public Health and Tropical Medicine, New Orleans, LA 70112, USA
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Department of Epidemiology, Tulane University School of Public Health and Tropical Medicine, New Orleans, LA 70112, USA
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Section of Hematology and Medical Oncology, Tulane University School of Medicine, New Orleans, LA 70112, USA
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University of Washington, Washington Center for Bleeding Disorders at Bloodworks Northwest, Seattle, WA 98195, USA
*
Author to whom correspondence should be addressed.
Nutrients 2018, 10(10), 1384; https://doi.org/10.3390/nu10101384
Received: 12 August 2018 / Revised: 19 September 2018 / Accepted: 20 September 2018 / Published: 29 September 2018
Sickle cell disease (SCD) is a genetic disorder resulting from the presence of mutated hemoglobin S (HbS). Homozygous carriers will present with early manifestations of painful vaso-occlusive crises. SCD patients have been reported to be severely deficient in vitamin D (<20 ng/mL). Four years (2010–2014) of individual de-identified Sickle Cell Clinic of Southern Louisiana (SCCSL-SCD) patient records were analyzed for vitamin D status and the level of crisis-related ER/hospital utilization. To determine the dietary, and behavioral mediators of SCD-crisis in our study population, a cohort of 102 SCCSL-SCD patients were administered a survey that evaluated sun exposure, dietary behaviors, and pain frequency and severity. Patients with circulating levels of 25(OH)D3 less than 14.1 ng/mL reported having more crisis-related hospital visits per year (10) than patients with 25(OH)D3 serum levels >34 ng/mL. The result of the dietary survey detailed a relationship between patients who reported to have “Almost Never” consumed fish or milk in their diets and more frequent hospital stays and ER visits than those who reported consuming these products on a daily basis. Those who consumed these foods in their diet several times a month also had fewer ER visits when compared to the “Almost Never” category. View Full-Text
Keywords: sickle cell disease; sickle cell crisis; vitamin D; diet sickle cell disease; sickle cell crisis; vitamin D; diet
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McCaskill, M.L.; Ogunsakin, O.; Hottor, T.; Harville, E.W.; Kruse-Jarres, R. Serum 25-Hydroxyvitamin D and Diet Mediates Vaso-Occlusive Related Hospitalizations in Sickle-Cell Disease Patients. Nutrients 2018, 10, 1384.

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