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Open AccessArticle

Possible Mechanisms of the Prevention of Doxorubicin Toxicity by Cichoric Acid—Antioxidant Nutrient

1
Department of Chemistry, Biology and Biotechnology, Faculty of Civil Engineering and Environmental Engineering, Białystok University of Technology, Wiejska 45E Street, 15-351 Białystok, Poland
2
Department of Pharmaceutical Biochemistry, Medical University of Bialystok, 15-222 Białystok, Poland
*
Author to whom correspondence should be addressed.
Nutrients 2018, 10(1), 44; https://doi.org/10.3390/nu10010044
Received: 10 November 2017 / Revised: 2 January 2018 / Accepted: 3 January 2018 / Published: 5 January 2018
(This article belongs to the Special Issue Nutraceuticals and the Skin: Roles in Health and Disease)
Skin is the largest organ in the human body, and which protects organism against unfavorable external factors e.g., chemicals, environment pollutants, allergens, microorganisms, and it plays a crucial role in maintaining general homeostasis. It is also an important target of oxidative stress due to the activity of oxygen reactive species (ROS), which are constantly generated in the fibroblasts in response to exogenous or endogenous prooxidant agents. An example of such compound with proved prooxidant activity is Doxorubicin (DOX), which is an effective anticancer agent belongs in anthracycline antibiotic group. Increasingly frequent implementation of various strategies to reduce undesirable DOX side effects was observed. Very promising results come from the combination of DOX with dietary antioxidants from the polyphenol group of compounds, such as cichoric acid (CA) in order to lower oxidative stress level. The aim of this work was to evaluate the influence of CA combined with DOX on the oxidative stress parameters in fibroblasts, which constitute the main cells in human skin. We also wanted to examine anti-apoptotic activity of CA in fibroblasts treated with selected concentrations of DOX. Results obtained from the combination of DOX with CA revealed that CA exhibits cytoprotective activity against DOX-induced damage by lowering oxidative stress level and by inhibiting apoptosis. The present finding may indicate that CA may serve as antioxidative and anti-apoptotic agent, active against DOX-induced damage. View Full-Text
Keywords: cichoric acid; doxorubicin; fibroblasts; skin; oxidative stress cichoric acid; doxorubicin; fibroblasts; skin; oxidative stress
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Jabłońska-Trypuć, A.; Krętowski, R.; Kalinowska, M.; Świderski, G.; Cechowska-Pasko, M.; Lewandowski, W. Possible Mechanisms of the Prevention of Doxorubicin Toxicity by Cichoric Acid—Antioxidant Nutrient. Nutrients 2018, 10, 44.

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