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Clinics and Practice
Volume 9
Issue 2
10.4081/cp.2019.1157
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Clinics and Practice is published by MDPI from Volume 11 Issue 1 (2021). Previous articles were published by another publisher in Open Access under a CC-BY (or CC-BY-NC-ND) licence, and they are hosted by MDPI on mdpi.com as a courtesy and upon agreement with PAGEPress.
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Case Report

Recurrent Amelanotic Melanoma of Nasal Cavity: Biological Variability and Unpredictable Behavior of Mucosal Melanoma. A Case Report

by
Damir Vučinić
1,*,
Dag Zahirović
2,
Dubravko Manestar
1,3,
Ingrid Belac-Lovasić
1,2,
Tamara Braut
1,3,
Leo Kovač
4,
Nives Jonjić
4 and
Gordana Zamolo
4
1
Faculty of Medicine, University of Rijeka, Rijeka, Croatia
2
Department of Radiotherapy and Oncology, Clinical Hospital Centre Rijeka, Rijeka, Croatia
3
Clinic of Otorhinolaryngology, Head and Neck Surgery, Clinical Hospital Centre Rijeka, Rijeka, Croatia
4
Department of Pathology, Faculty of Medicine, University of Rijeka, Rijeka, Croatia
*
Author to whom correspondence should be addressed.
Clin. Pract. 2019, 9(2), 1157; https://doi.org/10.4081/cp.2019.1157
Submission received: 12 April 2019 / Revised: 27 May 2019 / Accepted: 27 May 2019 / Published: 11 June 2019

Abstract

The aim of this report is to present a case of a patient with a recurrent nasal cavity amelanotic melanoma (AM), with emphasis on diagnosis and therapy options of this clinical entity. A 65-year-old female patient presented with pain in the right cheek region and nasal obstruction. In 2013, she was diagnosed with mucosal melanoma (MM) of the left nasal cavity. After endoscopic surgery and radiotherapy, the patient was followed by the oncology team. Five years after the initial diagnosis, rhinoscopy showed a tumorous formation in the right nasal cavity. The tumor mass was without black discoloration and was the same color as the surrounding nasal mucosa. Microscopic examination after biopsy of the tumor confirmed amelanotic MM. The patient underwent an additional endoscopic surgery. A complete standard diagnostic workup for MM found metastases in head and neck lymph nodes, on both sides. MMs of head and neck are uncommon malignancies. Unique biology of MM cells causes a high rate of recurrences. This report presents an example of recurrent AM of the nasal cavity, in treatment with checkpoint inhibitor (pembrolizumab), which could provide a good therapy option for patients with MM.
Keywords: amelanotic melanoma; nasal cavity; mucosal melanoma; immunotherapy; radiotherapy amelanotic melanoma; nasal cavity; mucosal melanoma; immunotherapy; radiotherapy

Share and Cite

MDPI and ACS Style

Vučinić, D.; Zahirović, D.; Manestar, D.; Belac-Lovasić, I.; Braut, T.; Kovač, L.; Jonjić, N.; Zamolo, G. Recurrent Amelanotic Melanoma of Nasal Cavity: Biological Variability and Unpredictable Behavior of Mucosal Melanoma. A Case Report. Clin. Pract. 2019, 9, 1157. https://doi.org/10.4081/cp.2019.1157

AMA Style

Vučinić D, Zahirović D, Manestar D, Belac-Lovasić I, Braut T, Kovač L, Jonjić N, Zamolo G. Recurrent Amelanotic Melanoma of Nasal Cavity: Biological Variability and Unpredictable Behavior of Mucosal Melanoma. A Case Report. Clinics and Practice. 2019; 9(2):1157. https://doi.org/10.4081/cp.2019.1157

Chicago/Turabian Style

Vučinić, Damir, Dag Zahirović, Dubravko Manestar, Ingrid Belac-Lovasić, Tamara Braut, Leo Kovač, Nives Jonjić, and Gordana Zamolo. 2019. "Recurrent Amelanotic Melanoma of Nasal Cavity: Biological Variability and Unpredictable Behavior of Mucosal Melanoma. A Case Report" Clinics and Practice 9, no. 2: 1157. https://doi.org/10.4081/cp.2019.1157

APA Style

Vučinić, D., Zahirović, D., Manestar, D., Belac-Lovasić, I., Braut, T., Kovač, L., Jonjić, N., & Zamolo, G. (2019). Recurrent Amelanotic Melanoma of Nasal Cavity: Biological Variability and Unpredictable Behavior of Mucosal Melanoma. A Case Report. Clinics and Practice, 9(2), 1157. https://doi.org/10.4081/cp.2019.1157

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