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Clinics and Practice
Volume 7
Issue 1
10.4081/cp.2017.912
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Clinics and Practice is published by MDPI from Volume 11 Issue 1 (2021). Previous articles were published by another publisher in Open Access under a CC-BY (or CC-BY-NC-ND) licence, and they are hosted by MDPI on mdpi.com as a courtesy and upon agreement with PAGEPress.
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Brief Report

Combination Iron Chelation Therapy with Deferiprone and Deferasirox in Iron-Overloaded Patients with Transfusiondependent β-thalassemia Major

by
Hossein Karami
1,
Mehrnoush Kosaryan
1,*,
Arash Hadian Amree
2,
Hadi Darvishi-Khezri
2 and
Masoomeh Mousavi
3
1
Department of Pediatrics, Thalassemia Research Center, Hemoglobinopathy Institute, Mazandaran University of Medical Sciences, Sari, Iran
2
Student Research Committee, Thalassemia Research Center, Hemoglobinopathy Institute, Mazandaran University of Medical Sciences, Sari, Iran
3
Department of Anesthesiology, Babol University of Medical Sciences, Babol, Iran
*
Author to whom correspondence should be addressed.
Clin. Pract. 2017, 7(1), 912; https://doi.org/10.4081/cp.2017.912
Submission received: 30 September 2016 / Revised: 18 December 2016 / Accepted: 28 December 2016 / Published: 12 January 2017

Abstract

There are few papers on the combination therapy of deferiprone (DFP) and deferasirox (DFX) in iron-overloaded patients with transfusion-dependent β-thalassemia major (β-TM). A total of 6 patients with β-TM (5 males and 1 female) with a mean age of 23.8±5.8 years (ranging from 17 to 31) used this treatment regimen. The mean doses of DFP and DFX were 53.9±22.2 and 29.3±6.8 mg/kg/day, respectively. The duration of treatment was 11.5±4.6 months. Their serum ferritin levels were measured to be 2800±1900 and 3400±1600 ng/mL before and after treatment, respectively (p<0.6). Their cardiac magnetic resonance imaging (MRI) T2* values were 16.69±15.35 vs 17.38±5.74 millisecond (ms) before and after treatment, respectively (p < 0.9). Although there was no significant difference between their cardiac MRI T2* values before and after treatment statistically, the values improved after combination therapy with DFP and DFX in most of the patients. Liver MRI T2 * values were changed from 2.12±0.98 to 3.03±1.51 ms after treatment (p < 0.01); Further, their liver T2* values and liver iron concentration (LIC) were improved after treatment. Our study found that cardiac MRI T2* values, liver MRI T2* values, and LIC were improved after combination therapy with DFP and DFX in β-TM patients and that DFP and DFX combination therapy could be used to alleviate cardiac and liver iron loading.
Keywords: deferiprone; deferasirox; iron overload; β-thalassemia major; MRI T2* deferiprone; deferasirox; iron overload; β-thalassemia major; MRI T2*

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MDPI and ACS Style

Karami, H.; Kosaryan, M.; Hadian Amree, A.; Darvishi-Khezri, H.; Mousavi, M. Combination Iron Chelation Therapy with Deferiprone and Deferasirox in Iron-Overloaded Patients with Transfusiondependent β-thalassemia Major. Clin. Pract. 2017, 7, 912. https://doi.org/10.4081/cp.2017.912

AMA Style

Karami H, Kosaryan M, Hadian Amree A, Darvishi-Khezri H, Mousavi M. Combination Iron Chelation Therapy with Deferiprone and Deferasirox in Iron-Overloaded Patients with Transfusiondependent β-thalassemia Major. Clinics and Practice. 2017; 7(1):912. https://doi.org/10.4081/cp.2017.912

Chicago/Turabian Style

Karami, Hossein, Mehrnoush Kosaryan, Arash Hadian Amree, Hadi Darvishi-Khezri, and Masoomeh Mousavi. 2017. "Combination Iron Chelation Therapy with Deferiprone and Deferasirox in Iron-Overloaded Patients with Transfusiondependent β-thalassemia Major" Clinics and Practice 7, no. 1: 912. https://doi.org/10.4081/cp.2017.912

APA Style

Karami, H., Kosaryan, M., Hadian Amree, A., Darvishi-Khezri, H., & Mousavi, M. (2017). Combination Iron Chelation Therapy with Deferiprone and Deferasirox in Iron-Overloaded Patients with Transfusiondependent β-thalassemia Major. Clinics and Practice, 7(1), 912. https://doi.org/10.4081/cp.2017.912

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