Association Between General Practitioner’s Sex and Documented Diagnoses of Female-Specific Disorders in German Primary Care: A Large Matched Cross-Sectional Study
Abstract
1. Introduction
2. Materials and Methods
2.1. Data Source
2.2. Study Design and Population
2.3. Study Outcomes and Statistical Analysis
3. Results
4. Discussion
5. Conclusions
Author Contributions
Funding
Institutional Review Board Statement
Informed Consent Statement
Data Availability Statement
Conflicts of Interest
References
- Blümel, M.; Spranger, A.; Achstetter, K.; Maresso, A.; Busse, R. Germany: Health System Review. Health Syst. Transit. 2020, 22, 1–272. [Google Scholar] [PubMed]
- Ramirez, A.G.; Wildes, K.A.; Nápoles-Springer, A.; Pérez-Stable, E.; Talavera, G.; Rios, E. Physician gender differences in general and cancer-specific prevention attitudes and practices. J. Cancer Educ. 2009, 24, 85–93. [Google Scholar] [CrossRef] [Scilit] [PubMed]
- Roter, D.L.; Hall, J.A.; Aoki, Y. Physician gender effects in medical communication: A meta-analytic review. JAMA 2002, 288, 756–764. [Google Scholar] [CrossRef] [Scilit] [PubMed]
- Jefferson, L.; Bloor, K.; Birks, Y.; Hewitt, C.; Bland, M. Effect of physicians’ gender on communication and consultation length: A systematic review and meta-analysis. J. Health Serv. Res. Policy 2013, 18, 242–248. [Google Scholar] [CrossRef] [Scilit] [PubMed]
- Delpech, R.; Bloy, G.; Panjo, H.; Falcoff, H.; Ringa, V.; Rigal, L. Physicians’ preventive practices: More frequently performed for male patients and by female physicians. BMC Health Serv. Res. 2020, 20, 331. [Google Scholar] [CrossRef] [Scilit] [PubMed]
- Janssen, S.M.; Lagro-Janssen, A.L.M. Physician’s gender, communication style, patient preferences and patient satisfaction in gynecology and obstetrics: A systematic review. Patient Educ. Couns. 2012, 89, 221–226. [Google Scholar] [CrossRef] [Scilit] [PubMed]
- Rathmann, W.; Bongaerts, B.; Carius, H.J.; Kruppert, S.; Kostev, K. Basic characteristics and representativeness of the German Disease Analyzer database. Int. J. Clin. Pharmacol. Ther. 2018, 56, 459–466. [Google Scholar] [CrossRef] [Scilit] [PubMed]
- Gremke, N.; Griewing, S.; Göhring, J.; Isselhard, A.; Wagner, U.; Kostev, K.; Kalder, M. Is there an association between endometriosis and subsequent breast cancer? A retrospective cohort study from Germany. Breast Cancer Res. Treat. 2024, 204, 359–365. [Google Scholar] [CrossRef] [Scilit] [PubMed]
- Krishnan, V.D.; Kostev, K.; Kalder, M. Is there an association between mastitis and breast cancer? A retrospective cohort study from Germany. Cancer Causes Control 2024, 35, 1517–1523. [Google Scholar] [CrossRef] [Scilit] [PubMed]
- Stuart, E.A.; Lee, B.K.; Leacy, F.P. Prognostic score-based balance measures for propensity score methods in comparative effectiveness research. J. Clin. Epidemiol. 2013, 66, S84–S90. [Google Scholar] [CrossRef] [Scilit] [PubMed]
- Flocke, S.A.; Gilchrist, V. Physician and patient gender concordance and the delivery of comprehensive clinical preventive services. Med. Care 2005, 43, 486–492. [Google Scholar] [CrossRef] [Scilit] [PubMed]
- Fink, M.; Klein, K.; Sayers, K.; Valentino, J.; Leonardi, C.; Bronstone, A.; Wiseman, P.M.; Dasa, V. Objective data reveals gender preferences for patients’ primary care physician. J. Prim. Care Community Health 2020, 11, 2150132720967221. [Google Scholar] [CrossRef] [Scilit] [PubMed]
- Eggermont, D.; Kunst, A.E.; Hek, K.; Verheij, R.A. Gender and age concordance between patient and GP: An observational study on associations with referral behaviour. BJGP Open 2022, 6, BJGPO.2022.0091. [Google Scholar] [CrossRef] [Scilit] [PubMed]
- Health Care Cost Institute. Data Brief: Menopause Diagnosis Steadily Increased from 2018–2022; HCCI: Washington, DC, USA, 2024; Available online: https://healthcostinstitute.org (accessed on 15 August 2026).
- Sussman, M.; Trocio, J.; Best, C.; Mirkin, S.; Bushmakin, A.G.; Yood, R.; Friedman, M.; Menzin, J.; Louie, M. Prevalence of menopausal symptoms among mid-life women: Findings from electronic medical records. BMC Women’s Health 2015, 15, 58. [Google Scholar] [CrossRef] [Scilit] [PubMed]
- Trusch, B.; Heintze, C.; Petelos, E.; Dini, L. Collaboration amongst general practitioners and gynaecologists working in primary health care in Germany: A cross-sectional study. Prim. Health Care Res. Dev. 2021, 22, e42. [Google Scholar] [CrossRef] [Scilit] [PubMed]
- Briscoe, S.; Thompson Coon, J.; Melendez-Torres, G.J.; Abbott, R.; Shaw, L.; Nunns, M.; Garside, R. Primary care clinicians’ perspectives on interacting with patients with gynaecological conditions: A systematic review. BJGP Open 2024, 8, BJGPO.2023.0133. [Google Scholar] [CrossRef] [Scilit] [PubMed]
- Boulis, A.K.; Long, J.A. Gender differences in the practice of adult primary care physicians. J. Womens Health 2004, 13, 703–712. [Google Scholar] [CrossRef] [Scilit] [PubMed]

| Variable | Individuals Seen by Female GPs (n = 661,485) | Individuals Seen by Male GPs (n = 661,485) | SMD |
|---|---|---|---|
| Mean age, years (SD) | 54.3 (20.0) | 54.4 (20.1) | 0.001 |
| Age 18–30 years, n (%) | 98,856 (14.9) | 100,765 (15.2) | |
| Age 31–45 years, n (%) | 140,351 (21.2) | 138,752 (21.0) | |
| Age 46–60 years, n (%) | 154,686 (23.4) | 154,064 (23.3) | |
| Age 61–75 years, n (%) | 155,294 (23.5) | 151,935 (23.0) | |
| Age > 75 years, n (%) | 112,298 (17.0) | 115,969 (17.5) | |
| Statutory health insurance, n (%) | 616,309 (93.2) | 613,802 (92.8) | 0.015 |
| Private health insurance, n (%) | 45,176 (6.8) | 47,683 (7.2) | |
| Patients seen per physician in 2025, median (IQR) | 1380 (933) | 1324 (946) | 0.004 |
| Consultations per patient in 2025, median (IQR) | 3 (5) | 3 (4) | 0.010 |
| van Walraven comorbidity score (excl. malignancy), mean (SD) | 0.92 (3.29) | 0.93 (3.26) | 0.003 |
| Condition (ICD-10) | Age Group, Years | Prevalence per 1000, Female GPs | Prevalence per 1000, Male GPs | OR (95% CI) | p-Value | p for Interaction (Age × GP Sex) |
|---|---|---|---|---|---|---|
| Endometriosis (N80) | 18–30 | 4.82 | 4.98 | 1.02 (0.88–1.18) | 0.828 | <0.001 |
| 31–45 | 6.12 | 5.59 | 1.15 (1.03–1.28) | 0.014 | ||
| 46–60 | 2.11 | 2.07 | 1.06 (0.89–1.25) | 0.523 | ||
| Mastitis (N61) | 18–30 | 0.81 | 0.61 | 1.39 (0.94–2.05) | 0.096 | <0.001 |
| 31–45 | 1.10 | 0.88 | 1.21 (0.93–1.58) | 0.154 | ||
| 46–60 | 0.50 | 0.49 | 0.92 (0.65–1.31) | 0.638 | ||
| Menopausal and other perimenopausal disorders (N95) | 31–45 | 2.08 | 1.61 | 1.32 (1.09–1.60) | 0.005 | <0.001 |
| 46–60 | 17.84 | 12.98 | 1.37 (1.28–1.46) | <0.001 | ||
| 61–75 | 8.47 | 8.53 | 0.99 (0.91–1.08) | 0.884 | ||
| >75 | 7.12 | 8.55 | 0.81 (0.72–0.90) | <0.001 | ||
| Menstrual cycle disorders (N91–N94) | 18–30 | 32.20 | 36.38 | 0.90 (0.85–0.95) | <0.001 | <0.001 |
| 31–45 | 14.60 | 13.98 | 1.03 (0.96–1.10) | 0.465 | ||
| 46–60 | 6.46 | 6.09 | 1.05 (0.95–1.17) | 0.296 | ||
| Pregnancy, childbirth and the puerperium (O00–O99, Z32–Z39) | 18–30 | 21.67 | 22.14 | 0.98 (0.91–1.05) | 0.579 | <0.001 |
| 31–45 | 24.80 | 23.29 | 1.08 (1.02–1.14) | 0.008 | ||
| Benign neoplasm of female breast and genital organs (D24–D28) | 18–30 | 0.75 | 0.72 | 1.12 (0.75–1.67) | 0.582 | 0.137 |
| 31–45 | 2.99 | 2.82 | 1.08 (0.92–1.26) | 0.357 | ||
| 46–60 | 5.17 | 4.79 | 1.16 (1.04–1.29) | 0.010 | ||
| 61–75 | 3.00 | 2.86 | 1.04 (0.90–1.20) | 0.617 | ||
| >75 | 1.59 | 1.88 | 0.88 (0.70–1.11) | 0.282 | ||
| Breast cancer (C50) | 18–30 | 0.84 | 0.69 | 1.08 (0.74–1.58) | 0.696 | <0.001 |
| 31–45 | 3.15 | 3.37 | 0.87 (0.75–1.00) | 0.059 | ||
| 46–60 | 10.82 | 11.61 | 0.94 (0.87–1.01) | 0.100 | ||
| 61–75 | 17.81 | 17.97 | 1.00 (0.94–1.06) | 0.923 | ||
| >75 | 22.73 | 21.30 | 1.06 (0.99–1.13) | 0.074 | ||
| Female genital organ cancer (C51–C57) | 18–30 | 0.22 | 0.27 | 1.01 (0.52–1.95) | 0.978 | <0.001 |
| 31–45 | 1.28 | 1.27 | 1.03 (0.81–1.31) | 0.797 | ||
| 46–60 | 2.95 | 3.19 | 0.92 (0.80–1.06) | 0.236 | ||
| 61–75 | 4.57 | 4.90 | 0.92 (0.82–1.03) | 0.153 | ||
| >75 | 5.27 | 4.83 | 1.04 (0.91–1.19) | 0.542 |
| Condition (ICD-10) | Age Group, Years | OR (95% CI) | E-Value (Point Estimate) | E-Value (CI Limit Closest to Null) |
|---|---|---|---|---|
| Endometriosis (N80) | 31–45 | 1.15 (1.03–1.28) | 1.56 | 1.19 |
| Menopausal and other perimenopausal disorders (N95) | 31–45 | 1.32 (1.09–1.60) | 1.97 | 1.39 |
| Menopausal and other perimenopausal disorders (N95) | 46–60 | 1.37 (1.28–1.46) | 2.08 | 1.89 |
| Menopausal and other perimenopausal disorders (N95) | >75 | 0.81 (0.72–0.90) | 1.78 | 1.46 |
| Menstrual cycle disorders (N91–N94) | 18–30 | 0.90 (0.85–0.95) | 1.48 | 1.29 |
| Pregnancy, childbirth and the puerperium (O00–O99, Z32–Z39) | 31–45 | 1.08 (1.02–1.14) | 1.36 | 1.16 |
| Benign neoplasm of female breast and genital organs (D24–D28) | 46–60 | 1.16 (1.04–1.29) | 1.59 | 1.23 |
Disclaimer/Publisher’s Note: The statements, opinions and data contained in all publications are solely those of the individual author(s) and contributor(s) and not of MDPI and/or the editor(s). MDPI and/or the editor(s) disclaim responsibility for any injury to people or property resulting from any ideas, methods, instructions or products referred to in the content. |
© 2026 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license.
Share and Cite
Kostev, K.; Rodemer, I.; Konrad, M.; Kalder, M. Association Between General Practitioner’s Sex and Documented Diagnoses of Female-Specific Disorders in German Primary Care: A Large Matched Cross-Sectional Study. Clin. Pract. 2026, 16, 152. https://doi.org/10.3390/clinpract16080152
Kostev K, Rodemer I, Konrad M, Kalder M. Association Between General Practitioner’s Sex and Documented Diagnoses of Female-Specific Disorders in German Primary Care: A Large Matched Cross-Sectional Study. Clinics and Practice. 2026; 16(8):152. https://doi.org/10.3390/clinpract16080152
Chicago/Turabian StyleKostev, Karel, Ira Rodemer, Marcel Konrad, and Matthias Kalder. 2026. "Association Between General Practitioner’s Sex and Documented Diagnoses of Female-Specific Disorders in German Primary Care: A Large Matched Cross-Sectional Study" Clinics and Practice 16, no. 8: 152. https://doi.org/10.3390/clinpract16080152
APA StyleKostev, K., Rodemer, I., Konrad, M., & Kalder, M. (2026). Association Between General Practitioner’s Sex and Documented Diagnoses of Female-Specific Disorders in German Primary Care: A Large Matched Cross-Sectional Study. Clinics and Practice, 16(8), 152. https://doi.org/10.3390/clinpract16080152

