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Review

New Aspects of Sarcomas of Uterine Corpus—A Brief Narrative Review

1
Department of Gynecology, St. Anna University Hospital, Medical University of Varna, 9002 Varna, Bulgaria
2
Department of General and Clinical Pathology, Faculty of Medicine, Medical University Sofia, 2 Zdrave Str., 1432 Sofia, Bulgaria
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Department of General and Clinical Pathology, Forensic Medicine and Deontology, Division of General and Clinical Pathology, Faculty of Medicine, Medical University—Varna “Prof. Dr. Paraskev Stoyanov”, 9002 Varna, Bulgaria
4
Clinical Pathology Laboratory, MHAT “Nadezda” Women’s Health Hospital, 1373 Sofia, Bulgaria
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Neuropathological Laboratory, University Hospital “Saint Ivan Rilski”, 1431 Sofia, Bulgaria
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Faculty Associate, Medical Center—University of Freiburg, 79106 Freiburg, Germany
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University Hospital SBALAG “Maichin Dom”, Medical University Sofia, 1000 Sofia, Bulgaria
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Department of Gynecologic Oncology, Medical University Pleven, 5800 Pleven, Bulgaria
*
Author to whom correspondence should be addressed.
Academic Editors: Antonella Romanini and Aya Mousa
Clin. Pract. 2021, 11(4), 878-900; https://doi.org/10.3390/clinpract11040103
Received: 10 September 2021 / Revised: 11 November 2021 / Accepted: 16 November 2021 / Published: 22 November 2021
Sarcomas of the uterine corpus are rare malignant neoplasms, which are further classified into mesenchymal tumors, and mixed (epithelial plus mesenchymal) tumors. The main issues concerning these neoplasms are the small number of clinical trials, insufficient data from evidence-based medicine, insignificant interest from the pharmaceutical industry, all of which close a vicious circle. The low frequency of these malignancies implies insufficient experience in the diagnosis, hence incomplete surgical and complex treatment. Additionally, the rarity of these sarcomas makes it very difficult to develop clinical practice guidelines. Preoperative diagnosis, neoadjuvant and adjuvant chemoradiation, target and hormone therapies still raise many controversies. Disagreements about the role and type of surgical treatment are also often observed in medical literature. There are still insufficient data about the role of pelvic lymph node dissection and fertility-sparing surgery. Pathologists’ experience is of paramount importance for an accurate diagnosis. Additionally, genetics examinations become part of diagnosis in some sarcomas of the uterine corpus. Some gene mutations observed in uterine sarcomas are associated with different outcomes. Therefore, a development of molecular classification of uterine sarcomas should be considered in the future. In this review, we focus on the epidemiology, pathogenesis, pathology, diagnosis and treatment of the following sarcomas of the uterine corpus: leiomyosarcoma, low- and high-grade endometrial stromal sarcomas, undifferentiated sarcoma and adenosarcoma. Uterine carcinosarcomas are excluded as they represent an epithelial tumor rather than a true sarcoma. View Full-Text
Keywords: uterine leiomyosarcoma; low-grade endometrial stromal sarcoma; high-grade endometrial stromal sarcoma; undifferentiated uterine sarcoma; uterine adenosarcoma uterine leiomyosarcoma; low-grade endometrial stromal sarcoma; high-grade endometrial stromal sarcoma; undifferentiated uterine sarcoma; uterine adenosarcoma
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MDPI and ACS Style

Kostov, S.; Kornovski, Y.; Ivanova, V.; Dzhenkov, D.; Metodiev, D.; Watrowski, R.; Ivanova, Y.; Slavchev, S.; Mitev, D.; Yordanov, A. New Aspects of Sarcomas of Uterine Corpus—A Brief Narrative Review. Clin. Pract. 2021, 11, 878-900. https://doi.org/10.3390/clinpract11040103

AMA Style

Kostov S, Kornovski Y, Ivanova V, Dzhenkov D, Metodiev D, Watrowski R, Ivanova Y, Slavchev S, Mitev D, Yordanov A. New Aspects of Sarcomas of Uterine Corpus—A Brief Narrative Review. Clinics and Practice. 2021; 11(4):878-900. https://doi.org/10.3390/clinpract11040103

Chicago/Turabian Style

Kostov, Stoyan, Yavor Kornovski, Vesela Ivanova, Deyan Dzhenkov, Dimitar Metodiev, Rafał Watrowski, Yonka Ivanova, Stanislav Slavchev, Dimitar Mitev, and Angel Yordanov. 2021. "New Aspects of Sarcomas of Uterine Corpus—A Brief Narrative Review" Clinics and Practice 11, no. 4: 878-900. https://doi.org/10.3390/clinpract11040103

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