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Clinics and Practice
Volume 10
Issue 3
10.4081/cp.2020.1242
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Clinics and Practice is published by MDPI from Volume 11 Issue 1 (2021). Previous articles were published by another publisher in Open Access under a CC-BY (or CC-BY-NC-ND) licence, and they are hosted by MDPI on mdpi.com as a courtesy and upon agreement with PAGEPress.
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Case Report

Multiple Doses of Cell Therapy and Neurorehabilitation in Amyotrophic Lateral Sclerosis: A Case Report

by
Alok Sharma
,
Hemangi Sane
,
Amruta Paranjape
,
Radhika Pradhan
*,
Rohit Das
,
Hema Biju
,
Nandini Gokulchandran
and
Prerna Badhe
NeuroGen Brain and Spine Institute, Navi Mumbai, Maharashtra, India
*
Author to whom correspondence should be addressed.
Clin. Pract. 2020, 10(3), 1242; https://doi.org/10.4081/cp.2020.1242
Submission received: 31 January 2020 / Revised: 17 June 2020 / Accepted: 18 June 2020 / Published: 28 September 2020

Abstract

Cell therapy, along with intensive rehabilitation has been shown to significantly improve outcomes in amyotrophic lateral sclerosis (ALS), in addition to standard therapy. We present a 40-years-old male ALS patient, suffering for the past four years, who underwent multiple doses of cell therapy at our institution. Along with riluzole treatment and lithium co-administration, his treatment involved multiple intrathecal transplants of autologous bone marrow-derived mononuclear cells, followed by multidisciplinary neurorehabilitation. The outcome measures of ALSFunctional Rating Scale Revised score remained stable, and importantly, Six Minute Walk Test distance improved from 475.2 m to 580.8 m, over a span of 16 months. Improved outcomes are indicative of slowing down of disease progression. Multiple doses of intrathecal autologous cell therapy along with rehabilitation and lithium, in addition to standard riluzole treatment is a novel approach for decelerating disease progression and qualitatively improving living conditions for ALS patients and their caregivers.
Keywords: amyotrophic lateral sclerosis; bone marrow cells; cell therapy amyotrophic lateral sclerosis; bone marrow cells; cell therapy

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MDPI and ACS Style

Sharma, A.; Sane, H.; Paranjape, A.; Pradhan, R.; Das, R.; Biju, H.; Gokulchandran, N.; Badhe, P. Multiple Doses of Cell Therapy and Neurorehabilitation in Amyotrophic Lateral Sclerosis: A Case Report. Clin. Pract. 2020, 10, 1242. https://doi.org/10.4081/cp.2020.1242

AMA Style

Sharma A, Sane H, Paranjape A, Pradhan R, Das R, Biju H, Gokulchandran N, Badhe P. Multiple Doses of Cell Therapy and Neurorehabilitation in Amyotrophic Lateral Sclerosis: A Case Report. Clinics and Practice. 2020; 10(3):1242. https://doi.org/10.4081/cp.2020.1242

Chicago/Turabian Style

Sharma, Alok, Hemangi Sane, Amruta Paranjape, Radhika Pradhan, Rohit Das, Hema Biju, Nandini Gokulchandran, and Prerna Badhe. 2020. "Multiple Doses of Cell Therapy and Neurorehabilitation in Amyotrophic Lateral Sclerosis: A Case Report" Clinics and Practice 10, no. 3: 1242. https://doi.org/10.4081/cp.2020.1242

APA Style

Sharma, A., Sane, H., Paranjape, A., Pradhan, R., Das, R., Biju, H., Gokulchandran, N., & Badhe, P. (2020). Multiple Doses of Cell Therapy and Neurorehabilitation in Amyotrophic Lateral Sclerosis: A Case Report. Clinics and Practice, 10(3), 1242. https://doi.org/10.4081/cp.2020.1242

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