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Case Report

Pemetrexed Induced Pneumonitis

Medical College of Wisconsin, Milwaukee, WI, USA
*
Author to whom correspondence should be addressed.
Clin. Pract. 2011, 1(4), e106; https://doi.org/10.4081/cp.2011.e106
Submission received: 21 September 2011 / Revised: 20 October 2011 / Accepted: 21 October 2011 / Published: 8 November 2011

Abstract

Pemetrexed is an antifolate chemotherapy agent that is active in malignant mesothelioma and non-small cell lung cancer (NSCLC). Pneumonitis is a rare side effect of Pemetrexed. We report the case of 72-year-old female with metastatic poorly differentiated lung adenocarcinoma. She was placed on maintenance pemetrexed and developed gradual progressive dyspnea after first cycle of maintenance of pemextrexed. The computed tomography (CT) of the chest showed ground glass opacity in both lung fields. Transbronchial lung biopsy showed uniform interstitial widening by a cellular chronic infiltrate with areas of type II pneumocyte and exudation of pale eosinophilic edema fluid; features consistent with acute lung injury. Patient improved both clinically and radiological after stopping pemetrexed and starting prednisone. Although pemetrexed induced lung injury is relatively rare, with the increasing use of pemetrexed in first-line treatment and in maintenance therapy of non-small cell lung cancer, awareness of this potential adverse effects is important.
Keywords: pemetrexed; lung cancer; pneumonitis pemetrexed; lung cancer; pneumonitis

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MDPI and ACS Style

Dhakal, B.; Singh, V.; Shrestha, A.; Rao, A.; Choong, N. Pemetrexed Induced Pneumonitis. Clin. Pract. 2011, 1, e106. https://doi.org/10.4081/cp.2011.e106

AMA Style

Dhakal B, Singh V, Shrestha A, Rao A, Choong N. Pemetrexed Induced Pneumonitis. Clinics and Practice. 2011; 1(4):e106. https://doi.org/10.4081/cp.2011.e106

Chicago/Turabian Style

Dhakal, Binod, Veerpal Singh, Anuj Shrestha, Arjun Rao, and Nicholas Choong. 2011. "Pemetrexed Induced Pneumonitis" Clinics and Practice 1, no. 4: e106. https://doi.org/10.4081/cp.2011.e106

APA Style

Dhakal, B., Singh, V., Shrestha, A., Rao, A., & Choong, N. (2011). Pemetrexed Induced Pneumonitis. Clinics and Practice, 1(4), e106. https://doi.org/10.4081/cp.2011.e106

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