Carcinogenic Risk from Lead and Cadmium Contaminating Cow Milk and Soya Beverage Brands Available in the Portuguese Market
Abstract
:1. Introduction
2. Methods
2.1. Data Treatment
2.2. Carcinogenic Risk Assessments
2.2.1. Excess Lifetime Carcinogenic Risk
2.2.2. Metal Levels in Cow Milk and Soya Beverages
2.3. Carcinogenic Risk Assessment per Brand of Cow Milk or Soya Beverage
Relative Contribution of Pb and Cd to Carcinogenic Risk
2.4. Carcinogenic Risk Assessments in Several Scenarios of Daily Consumption of Cow Milk or Soya Beverage per Age/Weight
3. Results
Carcinogenic Risk Assessments per Brand of Cow Milk or Soya Beverage
4. Discussion
4.1. Children
4.2. Adolescents and Adults
4.3. Environmental Issues
5. Conclusions
Author Contributions
Funding
Institutional Review Board Statement
Informed Consent Statement
Data Availability Statement
Conflicts of Interest
References
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Parameter | Unit | Children | Adolescents | Adults | Source |
---|---|---|---|---|---|
Concentration (C) | mg/L | - | - | - | [14] |
Ingestion rate (IR) | L/day | 0.267 | 0.25 | 0.15 | [37] |
Exposure frequency (EF) | days/year | 365 (1) | 365 (1) | 365 (1) | |
Age (2) | years | 6 | 14 | 85 | [38] |
Exposure duration (ED) (2) | years | 5 | 13 | 84 | [16] |
Body weight (BW) (2) | Kg | 21 | 49 | 65 | [39,40] |
Average time (AT) | days | ED × 365 | ED × 365 | ED × 365 | [32] |
Cancer slope factor (CSF) | mg/kg/day | Pb: 0.28; Cd: 0.38 | [34] |
CM Brand | ELCR | Relative Contribution (%) | |||
---|---|---|---|---|---|
Pb | Cd | Pb Cd Aditivity | Pb | Cd | |
1 | 1.08 × 10−4 | 2.03 × 10−5 | 1.28 × 10−4 | 84.2 | 15.8 |
2 | 1.42 × 10−4 | 3.29 × 10−5 | 1.75 × 10−4 | 81.2 | 18.8 |
3 | 1.42 × 10−4 | 2.08 × 10−5 | 1.63 × 10−4 | 87.2 | 12.8 |
7 | 8.94 × 10−5 | 1.11 × 10−5 | 1.00 × 10−4 | 88.9 | 11.1 |
12 | 1.06 × 10−4 | 2.90 × 10−6 | 1.09 × 10−4 | 97.3 | 2.7 |
mean | 87.8 | 12.2 | |||
sd | 3.4 |
SB Brand | ELCR | Relative Contribution (%) | |||
---|---|---|---|---|---|
Pb | Cd | Pb Cd Aditivity | Pb | Cd | |
1 | 1.48 × 10−4 | 7.23 × 10−5 | 2.21 × 10−4 | 67.2 | 32.8 |
3 | 5.13 × 10−5 | 5.31 × 10−5 | 1.04 × 10−4 | 49.2 | 50.8 |
4 | 5.07 × 10−5 | 5.40 × 10−5 | 1.05 × 10−4 | 48.4 | 51.6 |
mean | 54.9 | 45.1 | |||
sd | 12.8 |
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de Andrade, V.L.; Ribeiro, I.; dos Santos, A.P.M.; Aschner, M.; Mateus, M.L. Carcinogenic Risk from Lead and Cadmium Contaminating Cow Milk and Soya Beverage Brands Available in the Portuguese Market. J. Xenobiot. 2024, 14, 798-811. https://doi.org/10.3390/jox14020045
de Andrade VL, Ribeiro I, dos Santos APM, Aschner M, Mateus ML. Carcinogenic Risk from Lead and Cadmium Contaminating Cow Milk and Soya Beverage Brands Available in the Portuguese Market. Journal of Xenobiotics. 2024; 14(2):798-811. https://doi.org/10.3390/jox14020045
Chicago/Turabian Stylede Andrade, Vanda Lopes, Iolanda Ribeiro, Ana Paula Marreilha dos Santos, Michael Aschner, and Maria Luisa Mateus. 2024. "Carcinogenic Risk from Lead and Cadmium Contaminating Cow Milk and Soya Beverage Brands Available in the Portuguese Market" Journal of Xenobiotics 14, no. 2: 798-811. https://doi.org/10.3390/jox14020045
APA Stylede Andrade, V. L., Ribeiro, I., dos Santos, A. P. M., Aschner, M., & Mateus, M. L. (2024). Carcinogenic Risk from Lead and Cadmium Contaminating Cow Milk and Soya Beverage Brands Available in the Portuguese Market. Journal of Xenobiotics, 14(2), 798-811. https://doi.org/10.3390/jox14020045