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Thalassemia Reports
Volume 7
Issue 1
10.4081/thal.2017.5860
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Thalassemia Reports is published by MDPI from Volume 12 Issue 1 (2022). Previous articles were published by another publisher in Open Access under a CC-BY (or CC-BY-NC-ND) licence, and they are hosted by MDPI on mdpi.com as a courtesy and upon agreement with PAGEPress.
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Case Report

Incidental Detection of a Rare Hemoglobin Variant (Hemoglobin N Seattle) Leading to Undetectable Levels of HbA1c in a Diabetic Female: A Case Report

by
Sarita Pradhan
1,*,
Sima Chauhan
1 and
Priyanka Samal
2
1
Department of Pathology, Siksha ‘O’ Anusandhan University, Bhubaneswar 751030, Odisha, India
2
Department of Clinical Hematology, IMS&SUM Hospital, Bhubaneswar, India
*
Author to whom correspondence should be addressed.
Thalass. Rep. 2017, 7(1), 5860; https://doi.org/10.4081/thal.2017.5860
Submission received: 2 March 2016 / Revised: 28 October 2016 / Accepted: 27 December 2016 / Published: 26 January 2017

Abstract

Glycosylated hemoglobin (GHb) is routinely used to monitor glycemic control over past 2–3 months in diabetics. As per the recommendations of the American Association of Clinical Endocrinologist, 2007 values should be maintained below 7% to prevent the risk of chronic complications. We report a case of a 55-year old female patient with spuriously low HbA1c values by high-performance liquid chromatography. Suspecting the presence of any abnormal hemoglobin, capillary zone electrophoresis was done which identified the presence of Hb variant corresponding to -Hb N Seattle. Our case highlights that clinical laboratories should be aware of limitations of their HbA1c assay methods as well as rule out any possible interfering Hb variants.
Keywords: hemoglobinopathies; HbA1c hemoglobinopathies; HbA1c

Share and Cite

MDPI and ACS Style

Pradhan, S.; Chauhan, S.; Samal, P. Incidental Detection of a Rare Hemoglobin Variant (Hemoglobin N Seattle) Leading to Undetectable Levels of HbA1c in a Diabetic Female: A Case Report. Thalass. Rep. 2017, 7, 5860. https://doi.org/10.4081/thal.2017.5860

AMA Style

Pradhan S, Chauhan S, Samal P. Incidental Detection of a Rare Hemoglobin Variant (Hemoglobin N Seattle) Leading to Undetectable Levels of HbA1c in a Diabetic Female: A Case Report. Thalassemia Reports. 2017; 7(1):5860. https://doi.org/10.4081/thal.2017.5860

Chicago/Turabian Style

Pradhan, Sarita, Sima Chauhan, and Priyanka Samal. 2017. "Incidental Detection of a Rare Hemoglobin Variant (Hemoglobin N Seattle) Leading to Undetectable Levels of HbA1c in a Diabetic Female: A Case Report" Thalassemia Reports 7, no. 1: 5860. https://doi.org/10.4081/thal.2017.5860

APA Style

Pradhan, S., Chauhan, S., & Samal, P. (2017). Incidental Detection of a Rare Hemoglobin Variant (Hemoglobin N Seattle) Leading to Undetectable Levels of HbA1c in a Diabetic Female: A Case Report. Thalassemia Reports, 7(1), 5860. https://doi.org/10.4081/thal.2017.5860

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