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Thalassemia Reports
Volume 4
Issue 2
10.4081/thal.2014.1853
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Thalassemia Reports is published by MDPI from Volume 12 Issue 1 (2022). Previous articles were published by another publisher in Open Access under a CC-BY (or CC-BY-NC-ND) licence, and they are hosted by MDPI on mdpi.com as a courtesy and upon agreement with PAGEPress.
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Article

Preimplantation HLA Typing for Stem Cell Transplantation Treatment of Hemoglobinopathies

by
Anver Kuliev
*,
Oleg Verlinsky
and
Svetlana Rechitsky
Anver Kuliev, Reproductive Genetics Institute, 2825 North Halsted Street, Chicago, IL 60657, USA
*
Author to whom correspondence should be addressed.
Thalass. Rep. 2014, 4(2), 1853; https://doi.org/10.4081/thal.2014.1853
Submission received: 30 July 2013 / Revised: 23 December 2013 / Accepted: 11 February 2014 / Published: 29 September 2014

Abstract

Preimplantation genetic diagnosis (PGD) for HLA typing is steadily becoming an option for at risk couples with thalassemic children, requiring HLA matched bone marrow transplantation treatment. The paper presents the world’s largest PGD experience of 475 cases for over 2 dozens thalassemia mutations, resulting in birth of 132 unaffected children. A total of 146 cases were performed together with preimplantation HLA typing, resulting in detection and transfer of HLA matched unaffected embryos in 83 of them, yielding the birth of 16 HLA matched children, potential donors for their affected siblings. The presented experience of HLA matched stem cell transplantation for thalassemia, following PGD demonstrated a successful hematopoietic reconstitution both for younger and older patients. The data show that PGD is an efficient approach for HLA matched stem cell transplantation treatment for thalassemia.
Keywords: preimplantation genetic diagnosis for hemoglobinopathies; preimplantation HLA typing; stem cell transplantation preimplantation genetic diagnosis for hemoglobinopathies; preimplantation HLA typing; stem cell transplantation

Share and Cite

MDPI and ACS Style

Kuliev, A.; Verlinsky, O.; Rechitsky, S. Preimplantation HLA Typing for Stem Cell Transplantation Treatment of Hemoglobinopathies. Thalass. Rep. 2014, 4, 1853. https://doi.org/10.4081/thal.2014.1853

AMA Style

Kuliev A, Verlinsky O, Rechitsky S. Preimplantation HLA Typing for Stem Cell Transplantation Treatment of Hemoglobinopathies. Thalassemia Reports. 2014; 4(2):1853. https://doi.org/10.4081/thal.2014.1853

Chicago/Turabian Style

Kuliev, Anver, Oleg Verlinsky, and Svetlana Rechitsky. 2014. "Preimplantation HLA Typing for Stem Cell Transplantation Treatment of Hemoglobinopathies" Thalassemia Reports 4, no. 2: 1853. https://doi.org/10.4081/thal.2014.1853

APA Style

Kuliev, A., Verlinsky, O., & Rechitsky, S. (2014). Preimplantation HLA Typing for Stem Cell Transplantation Treatment of Hemoglobinopathies. Thalassemia Reports, 4(2), 1853. https://doi.org/10.4081/thal.2014.1853

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