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Thalassemia Reports
Volume 3
Issue 1
10.4081/thal.2013.e6
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Thalassemia Reports is published by MDPI from Volume 12 Issue 1 (2022). Previous articles were published by another publisher in Open Access under a CC-BY (or CC-BY-NC-ND) licence, and they are hosted by MDPI on mdpi.com as a courtesy and upon agreement with PAGEPress.
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Article

Glutathione S Transferase Polymorphisms Influence on Iron Overload in β-Thalassemia Patients

by
Serena Sclafani
1,
Giuseppina Calvaruso
1,
Veronica Agrigento
1,
Aurelio Maggio
1,
Valeria Lo Nigro
2 and
Elena D’Alcamo
1,*
1
UOC Ematologia per le Malattie Rare del Sangue e degli Organi Ematopoietici, A.O.R. Villa Sofia Cervello, via Trabucco 180, 90146 Palermo, Italy
2
Dipartimento di Scienze Statistiche e Matematiche, Università degli Studi di Palermo, Italy
*
Author to whom correspondence should be addressed.
Thalass. Rep. 2013, 3(1), e6; https://doi.org/10.4081/thal.2013.e6
Submission received: 29 April 2013 / Accepted: 2 September 2013 / Published: 11 November 2013

Abstract

In patients with β-thalassemia iron overload that leads to damage to vital organs is observed. Glutathione S transferase (GST) enzymes have an antioxidant role in detoxification processes of toxic substances. This role is determined genetically. In this study, we correlated GSTT1 and GSTM1 genotypes with iron overload measured with direct and indirect non-invasive methods; in particular, we used serum ferritin and signal intensity of the magnetic resonance image (MRI) in 42 patients with β-thalassemia, which were regularly subjected to chelation and transfusion therapy. Multiplex polymerase chain reaction was used to determine the genotype. The loss of both alleles leads to a decreased value of liver and heart MRI-signal intensity with a consequent iron accumulation in these organs; the loss of only one allele doesn’t lead to relevant overload. Serum ferritin doesn’t appear to be correlated to iron overload instead.
Keywords: glutathione S transferases; β-thalassemia; iron overload glutathione S transferases; β-thalassemia; iron overload

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MDPI and ACS Style

Sclafani, S.; Calvaruso, G.; Agrigento, V.; Maggio, A.; Lo Nigro, V.; D’Alcamo, E. Glutathione S Transferase Polymorphisms Influence on Iron Overload in β-Thalassemia Patients. Thalass. Rep. 2013, 3, e6. https://doi.org/10.4081/thal.2013.e6

AMA Style

Sclafani S, Calvaruso G, Agrigento V, Maggio A, Lo Nigro V, D’Alcamo E. Glutathione S Transferase Polymorphisms Influence on Iron Overload in β-Thalassemia Patients. Thalassemia Reports. 2013; 3(1):e6. https://doi.org/10.4081/thal.2013.e6

Chicago/Turabian Style

Sclafani, Serena, Giuseppina Calvaruso, Veronica Agrigento, Aurelio Maggio, Valeria Lo Nigro, and Elena D’Alcamo. 2013. "Glutathione S Transferase Polymorphisms Influence on Iron Overload in β-Thalassemia Patients" Thalassemia Reports 3, no. 1: e6. https://doi.org/10.4081/thal.2013.e6

APA Style

Sclafani, S., Calvaruso, G., Agrigento, V., Maggio, A., Lo Nigro, V., & D’Alcamo, E. (2013). Glutathione S Transferase Polymorphisms Influence on Iron Overload in β-Thalassemia Patients. Thalassemia Reports, 3(1), e6. https://doi.org/10.4081/thal.2013.e6

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