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Review

Molecular Basis of α-thalassaemia

by
J. Traeger-Synodinos
Assistant Professor of Genetics, Medical Genetics, University of Athens, St. Sophia’s Children’s Hospital, Athens, Greece
Thalass. Rep. 2011, 1(s2), e13; https://doi.org/10.4081/thal.2011.s2.e13
Submission received: 1 December 2011 / Revised: 15 December 2011 / Accepted: 28 December 2011 / Published: 30 December 2011

Abstract

α-thalassaemia is an autosomal recessive disorder, in which there is impaired production of the a-globin chains of haemoglobin. It is associated with microcytic hypochromic anaemia, and a clinical phenotype varying from almost asymptomatic to a lethal haemolytic anaemia. It is probably the most common single gene disorder worldwide, and is especially frequent in populations originating from the Mediterranean region, SE Asia, Africa, Middle East and Indian subcontinent.
Keywords: thalassemia; molecular basis thalassemia; molecular basis

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MDPI and ACS Style

Traeger-Synodinos, J. Molecular Basis of α-thalassaemia. Thalass. Rep. 2011, 1, e13. https://doi.org/10.4081/thal.2011.s2.e13

AMA Style

Traeger-Synodinos J. Molecular Basis of α-thalassaemia. Thalassemia Reports. 2011; 1(s2):e13. https://doi.org/10.4081/thal.2011.s2.e13

Chicago/Turabian Style

Traeger-Synodinos, J. 2011. "Molecular Basis of α-thalassaemia" Thalassemia Reports 1, no. s2: e13. https://doi.org/10.4081/thal.2011.s2.e13

APA Style

Traeger-Synodinos, J. (2011). Molecular Basis of α-thalassaemia. Thalassemia Reports, 1(s2), e13. https://doi.org/10.4081/thal.2011.s2.e13

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