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Hematology Reports
Volume 9
Issue 2
10.4081/hr.2017.6961
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Case Report

Thalidomide for the Treatment of Gastrointestinal Bleeding Due to Angiodysplasia in a Patient with Glanzmann’s Thrombasthenia

by
Bruno K. L. Duarte
1,
Silvia M. de Souza
1,
Carolina Costa-Lima
1,
Samuel S. Medina
1 and
Margareth C. Ozelo
1,2,*
1
IHTC Haemophilia Unit Cláudio Luiz Pizzigatti Corrêa, Instituto Nacional de Ciência e Tecnologia do Sangue, Hemocentro Unicamp, University of Campinas, Rua Carlos Chagas 480, Campinas 13.083.878, SP, Brazil
2
Department of Internal Medicine, School of Medical Sciences, University of Campinas, Campinas 13.083.878, SP, Brazil
*
Author to whom correspondence should be addressed.
Hematol. Rep. 2017, 9(2), 6961; https://doi.org/10.4081/hr.2017.6961
Submission received: 10 November 2016 / Revised: 2 February 2017 / Accepted: 21 March 2017 / Published: 15 June 2017

Abstract

Angiodysplasia is a frequent cause of persistent gastrointestinal (GI) hemorrhage in elderly patients. Although GI bleeding isn’t the most common manifestation in patients with bleeding disorders, when present, it represents a challenging complication. We describe a 62-year-old patient with Glanzmann’s thrombasthenia, who used thalidomide for severe and recurrent GI bleeding. For 6 months, the patient experienced temporary control of GI bleeding with thalidomide in a daily oral dose of 100 mg. The anti-angiogenic effects of thalidomide have recently been explored by several groups, particularly in the management of bleeding from angiodysplasia, including cases with von Willebrand disease. Here, we review the relevant descriptions of the use of thalidomide in this situation, and also discuss potential reasons why we observed only a temporary control of the GI bleeding in our patient, such as the use of low-dose regimen due to limitations posed by thalidomide side effects.
Keywords: angiodysplasia; thalidomide; Glanzmann's thrombasthenia; gastrointestinal bleeding angiodysplasia; thalidomide; Glanzmann's thrombasthenia; gastrointestinal bleeding

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MDPI and ACS Style

Duarte, B.K.L.; de Souza, S.M.; Costa-Lima, C.; Medina, S.S.; Ozelo, M.C. Thalidomide for the Treatment of Gastrointestinal Bleeding Due to Angiodysplasia in a Patient with Glanzmann’s Thrombasthenia. Hematol. Rep. 2017, 9, 6961. https://doi.org/10.4081/hr.2017.6961

AMA Style

Duarte BKL, de Souza SM, Costa-Lima C, Medina SS, Ozelo MC. Thalidomide for the Treatment of Gastrointestinal Bleeding Due to Angiodysplasia in a Patient with Glanzmann’s Thrombasthenia. Hematology Reports. 2017; 9(2):6961. https://doi.org/10.4081/hr.2017.6961

Chicago/Turabian Style

Duarte, Bruno K. L., Silvia M. de Souza, Carolina Costa-Lima, Samuel S. Medina, and Margareth C. Ozelo. 2017. "Thalidomide for the Treatment of Gastrointestinal Bleeding Due to Angiodysplasia in a Patient with Glanzmann’s Thrombasthenia" Hematology Reports 9, no. 2: 6961. https://doi.org/10.4081/hr.2017.6961

APA Style

Duarte, B. K. L., de Souza, S. M., Costa-Lima, C., Medina, S. S., & Ozelo, M. C. (2017). Thalidomide for the Treatment of Gastrointestinal Bleeding Due to Angiodysplasia in a Patient with Glanzmann’s Thrombasthenia. Hematology Reports, 9(2), 6961. https://doi.org/10.4081/hr.2017.6961

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