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Hematology Reports
Volume 9
Issue 1
10.4081/hr.2017.6995
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Hematology Reports is published by MDPI from Volume 14 Issue 1 (2022). Previous articles were published by another publisher in Open Access under a CC-BY (or CC-BY-NC-ND) licence, and they are hosted by MDPI on mdpi.com as a courtesy and upon agreement with PAGEPress.
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Case Report

A 80-Year-Old Woman with B-Cell Prolymphocytic Leukemia

by
Alparslan Merdin
1,*,
Jale Yildiz
1,
Mehmet Sinan Dal
1,
Merih Kızıl Çakar
1,
Hikmetullah Batgi
1,
Emre Tekgündüz
1,
Aykut Onursever
2 and
Fevzi Altuntaş
1
1
Hematology Clinic and Bone Marrow Transplantation Unit, Dr. Abdurrahman Yurtaslan Oncology Training and Research Hospital, Mehmet Akif Ersoy Mh., 13. Cadde No: 56, Mehmet Akif Ersoy, 06200 Ankara, Turkey
2
Pathology Clinic, Dr. Abdurrahman Yurtaslan Oncology Training and Research Hospital, 06200 Ankara, Turkey
*
Author to whom correspondence should be addressed.
Hematol. Rep. 2017, 9(1), 6995; https://doi.org/10.4081/hr.2017.6995
Submission received: 2 December 2016 / Revised: 3 February 2017 / Accepted: 5 February 2017 / Published: 22 March 2017

Abstract

Prolymhocytic leukemia (PLL) is a rare subtype of lymphocytic leukemias and its cells are immature lymphocytes. It is divided into 2 subgroups: T-PLL and B-PLL according to the lymphocytic origin of the cells. Discriminating B-PLL from other diseases with clinically-similar features is important because of the different treatment approaches and follow-up programs. Hereby, we report a 80-year-old woman presenting with fatigue, leucocytosis and mild anemia. Her peripheral blood smear evaluation revealed 85% prolymphocytes with moderately condensed nuclear chromatin, prominent nucleoli, and a faintly basophilic cytoplasm. Positron emission tomography-computed tomography showed mediastinal lymph nodes with cervical lymph nodes. There was no pathological FDG involvement in the spleen. Bone marrow aspiration smear exhibit atypical wide lymphocytes with prominent nucleoli and abundant agranular cytoplasm. Flow cytometry analysis revealed positive CD5+, CD19+, CD20+, CD22+, CD11c+, CD25+, CD79a+ and CD79b+. Fluorescence in situ hybridization technique analysis reveals no t(11;14). Bone marrow biopsy revealed interstitially distributed atypical cells with wide nucleus and prominent nucleolus.
Keywords: B cell prolymphocytic leukemia; chronic lymphocytic leukemia B cell prolymphocytic leukemia; chronic lymphocytic leukemia

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MDPI and ACS Style

Merdin, A.; Yildiz, J.; Dal, M.S.; Çakar, M.K.; Batgi, H.; Tekgündüz, E.; Onursever, A.; Altuntaş, F. A 80-Year-Old Woman with B-Cell Prolymphocytic Leukemia. Hematol. Rep. 2017, 9, 6995. https://doi.org/10.4081/hr.2017.6995

AMA Style

Merdin A, Yildiz J, Dal MS, Çakar MK, Batgi H, Tekgündüz E, Onursever A, Altuntaş F. A 80-Year-Old Woman with B-Cell Prolymphocytic Leukemia. Hematology Reports. 2017; 9(1):6995. https://doi.org/10.4081/hr.2017.6995

Chicago/Turabian Style

Merdin, Alparslan, Jale Yildiz, Mehmet Sinan Dal, Merih Kızıl Çakar, Hikmetullah Batgi, Emre Tekgündüz, Aykut Onursever, and Fevzi Altuntaş. 2017. "A 80-Year-Old Woman with B-Cell Prolymphocytic Leukemia" Hematology Reports 9, no. 1: 6995. https://doi.org/10.4081/hr.2017.6995

APA Style

Merdin, A., Yildiz, J., Dal, M. S., Çakar, M. K., Batgi, H., Tekgündüz, E., Onursever, A., & Altuntaş, F. (2017). A 80-Year-Old Woman with B-Cell Prolymphocytic Leukemia. Hematology Reports, 9(1), 6995. https://doi.org/10.4081/hr.2017.6995

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