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Hematology Reports
Volume 9
Issue 1
10.4081/hr.2017.6862
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Hematology Reports is published by MDPI from Volume 14 Issue 1 (2022). Previous articles were published by another publisher in Open Access under a CC-BY (or CC-BY-NC-ND) licence, and they are hosted by MDPI on mdpi.com as a courtesy and upon agreement with PAGEPress.
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Case Report

Paroxysmal Nocturnal Hemoglobinuria in the Differential Diagnosis of Thrombocytopenia

by
Fusun Gediz
1,2,
Bahriye Kadriye Payzin
1,
Ozlem Zekiye Cakmak
3,
Yusuf Uzum
3,
Damla Ernur
4 and
Fahri Sahin
1,4,*
1
Department of Hematology, Izmir Katip Celebi University, Ataturk Training and Research Hospital, Izmir, Turkey
2
PNH Education and Study Gruop, Izmir, Turkey
3
Department of Internal Medicine Izmir Katip Celebi University, Ataturk Training and Research Hospital, Izmir, Turkey
4
Department of Hematology, Ege University, 35040 Bornova, Izmir, Turkey
*
Author to whom correspondence should be addressed.
Hematol. Rep. 2017, 9(1), 6862; https://doi.org/10.4081/hr.2017.6862
Submission received: 4 September 2016 / Revised: 13 November 2016 / Accepted: 17 November 2016 / Published: 22 March 2017

Abstract

Paroxysmal nocturnal hemoglobinuria (PNH) is a disease which diagnosis may be delayed due to variable clinical findings. We describe herein a case of PNH in a 21 year old woman who admitted with complaints of chronic weakness, intermittent spontaneous ecchymoses, and an intermittent abdominal pain. On laboratory tests thrombocytopenia and iron deficiency anemia without any clinical findings were found. Flow cytometric evaluations showed a PNH clone of 15% for erythrocytes, 64% for monocytes, and 60% for granulocytes. The patient was diagnosed with PNH and an eculizumab therapy was initiated. Following initiation of eculizumab therapy, the frequency of abdominal pain attacks decreased, hemoglobin level normalized, and platelet values increased slightly. In patients submitting with a triad of symptoms such as thrombocytopenia, iron deficiency anemia, and abdominal pain attacks of unknown etiology we suggest considering PNH. We also encourage physicians to share their similar observations in order to raise the knowledge on infrequent presentations of PNH.
Keywords: thrombocytopenia; abdominal pain; paroxysmal nocturnal hemoglobinuria thrombocytopenia; abdominal pain; paroxysmal nocturnal hemoglobinuria

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MDPI and ACS Style

Gediz, F.; Payzin, B.K.; Cakmak, O.Z.; Uzum, Y.; Ernur, D.; Sahin, F. Paroxysmal Nocturnal Hemoglobinuria in the Differential Diagnosis of Thrombocytopenia. Hematol. Rep. 2017, 9, 6862. https://doi.org/10.4081/hr.2017.6862

AMA Style

Gediz F, Payzin BK, Cakmak OZ, Uzum Y, Ernur D, Sahin F. Paroxysmal Nocturnal Hemoglobinuria in the Differential Diagnosis of Thrombocytopenia. Hematology Reports. 2017; 9(1):6862. https://doi.org/10.4081/hr.2017.6862

Chicago/Turabian Style

Gediz, Fusun, Bahriye Kadriye Payzin, Ozlem Zekiye Cakmak, Yusuf Uzum, Damla Ernur, and Fahri Sahin. 2017. "Paroxysmal Nocturnal Hemoglobinuria in the Differential Diagnosis of Thrombocytopenia" Hematology Reports 9, no. 1: 6862. https://doi.org/10.4081/hr.2017.6862

APA Style

Gediz, F., Payzin, B. K., Cakmak, O. Z., Uzum, Y., Ernur, D., & Sahin, F. (2017). Paroxysmal Nocturnal Hemoglobinuria in the Differential Diagnosis of Thrombocytopenia. Hematology Reports, 9(1), 6862. https://doi.org/10.4081/hr.2017.6862

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