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Hematology Reports
Volume 8
Issue 4
10.4081/hr.2016.6581
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Hematology Reports is published by MDPI from Volume 14 Issue 1 (2022). Previous articles were published by another publisher in Open Access under a CC-BY (or CC-BY-NC-ND) licence, and they are hosted by MDPI on mdpi.com as a courtesy and upon agreement with PAGEPress.
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Case Report

Successful Treatment of Immune Reconstitution Inflammatory Syndrome-Related Hemophagocytic Syndrome in an HIV Patient with Primary Effusion Lymphoma

by
Markela Pagonitsa Zorzou
1,*,
Maria Chini
1,
Athina Lioni
1,
Georgios Tsekes
1,
Thomas Nitsotolis
1,
Ioannis Tierris
2,
Nicolaos Panagiotou
3,
Dimitra Rontogianni
4,
Nicolaos Harhalakis
5 and
Marios Lazanas
1
1
Infectious Diseases Unit, Korgialeneio Benakeio General Hospital of Athens, Patelida Street 11, 82132 Chios, Greece
2
Surgery Department, Korgialeneio-Benakeio General Hospital of Athens, 11526 Athens, Greece
3
Hematology Department, Korgialeneio Benakeio General Hospital of Athens, 11526 Athens, Greece
4
Pathology Department, Evangelismos General Hospital of Athens, 11526 Athens, Greece
5
Hematology and Lymphoma Unit, Evangelismos General Hospital of Athens, 11526 Athens, Greece
*
Author to whom correspondence should be addressed.
Hematol. Rep. 2016, 8(4), 64-67; https://doi.org/10.4081/hr.2016.6581
Submission received: 5 May 2016 / Revised: 8 November 2016 / Accepted: 10 November 2016 / Published: 22 December 2016

Abstract

Although the connection of [secondary hemophagocytic syndrome (sHS)] with HIV has been well documented, optimal treatment regimen is not well established. This is due not only to the rarity of the syndrome, but also to the heterogeneity of the involved population. Most cases are related to opportunistic infections or malignancies in advanced stage, but many cases are also related to seroconversion, in the primary infection setting. Moreover, in the [antiretroviral treatment (ART)] era, rare cases of ART-related sHS have been reported. In these, often fatal cases, an [immune reconstitution inflammatory syndrome (IRIS)] process is involved, posing a serious challenge to the treating physician. We hereby report a case of successful treatment of an HIV patient with primary effusion lymphoma who experienced sHS shortly after ART onset. Our patient, treated with high dose dexamethasone and gamma globulin, achieved complete remission. This case might hint possible therapeutic insights in the treatment of IRIS-related sHS.
Keywords: hemophagocytic syndrome; immune reconstitution inflammatory syndrome; IRIS; HIV; ART hemophagocytic syndrome; immune reconstitution inflammatory syndrome; IRIS; HIV; ART

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MDPI and ACS Style

Zorzou, M.P.; Chini, M.; Lioni, A.; Tsekes, G.; Nitsotolis, T.; Tierris, I.; Panagiotou, N.; Rontogianni, D.; Harhalakis, N.; Lazanas, M. Successful Treatment of Immune Reconstitution Inflammatory Syndrome-Related Hemophagocytic Syndrome in an HIV Patient with Primary Effusion Lymphoma. Hematol. Rep. 2016, 8, 64-67. https://doi.org/10.4081/hr.2016.6581

AMA Style

Zorzou MP, Chini M, Lioni A, Tsekes G, Nitsotolis T, Tierris I, Panagiotou N, Rontogianni D, Harhalakis N, Lazanas M. Successful Treatment of Immune Reconstitution Inflammatory Syndrome-Related Hemophagocytic Syndrome in an HIV Patient with Primary Effusion Lymphoma. Hematology Reports. 2016; 8(4):64-67. https://doi.org/10.4081/hr.2016.6581

Chicago/Turabian Style

Zorzou, Markela Pagonitsa, Maria Chini, Athina Lioni, Georgios Tsekes, Thomas Nitsotolis, Ioannis Tierris, Nicolaos Panagiotou, Dimitra Rontogianni, Nicolaos Harhalakis, and Marios Lazanas. 2016. "Successful Treatment of Immune Reconstitution Inflammatory Syndrome-Related Hemophagocytic Syndrome in an HIV Patient with Primary Effusion Lymphoma" Hematology Reports 8, no. 4: 64-67. https://doi.org/10.4081/hr.2016.6581

APA Style

Zorzou, M. P., Chini, M., Lioni, A., Tsekes, G., Nitsotolis, T., Tierris, I., Panagiotou, N., Rontogianni, D., Harhalakis, N., & Lazanas, M. (2016). Successful Treatment of Immune Reconstitution Inflammatory Syndrome-Related Hemophagocytic Syndrome in an HIV Patient with Primary Effusion Lymphoma. Hematology Reports, 8(4), 64-67. https://doi.org/10.4081/hr.2016.6581

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