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Hematology Reports
Volume 7
Issue 4
10.4081/hr.2015.6043
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Brief Report

Docosahexaenoic Acid Induces Apoptosis in Primary Chronic Lymphocytic Leukemia Cells

by
Romain Guièze
1,2,*,
Emmanuel Gyan
3,4,
Olivier Tournilhac
1,2,
Christelle Halty
4,
Richard Veyrat-Masson
2,5,
Saïda Akil
5,
Marc Berger
2,5,
Olivier Hérault
4,
Mary Callanan
6,7,8 and
Jacques-Olivier Bay
4
1
Service de Thérapie Cellulaire et d’Hématologie Clinique Adulte, Hôpital Estaing, CHU de Clermont- Ferrand, 1 place Lucie Aubrac, 63000 Clermont-Ferrand, France
2
Cancer Resistance Exploring and Targeting EA 7283, Université d’Auvergne 1, Clermont-Ferrand, France
3
Service d’Hématologie et de thérapie cellulaire, Centre Hospitalier Universitaire, CHU de Tours, Clermont-Ferrand, France
4
Université François Rabelais, Tours, France
5
Laboratoire d’Hématologie, Hôpital Estaing, CHU de Clermont- Ferrand, Clermont-Ferrand, France
6
Joseph Fourier University, Grenoble, France
7
INSERM, U823, Institut Albert Bonniot, Grenoble, France
8
8Onco-Hematology Genetics Unit, Plateforme Hospitalière de Génétique Moléculaire des Tumeurs, Pôle de Biologie, CHU-Grenoble, Grenoble, France
*
Author to whom correspondence should be addressed.
Hematol. Rep. 2015, 7(4), 6043; https://doi.org/10.4081/hr.2015.6043
Submission received: 28 May 2015 / Revised: 15 September 2015 / Accepted: 20 October 2015 / Published: 17 December 2015

Abstract

Chronic lymphocytic leukemia is an indolent disorder with an increased infectious risk remaining one of the main causes of death. Development of therapies with higher safety profile is thus a challenging issue. Docosahexaenoic acid (DHA, 22:6) is an omega-3 fatty acid, a natural compound of normal cells, and has been shown to display antitumor potency in cancer. We evaluated the potential in vitro effect of DHA in primary CLL cells. DHA induces high level of in vitro apoptosis compared to oleic acid in a dose-dependent and time-dependent manner. Estimation of IC50 was only of 4.813 μM, which appears lower than those reported in solid cancers. DHA is highly active on CLL cells in vitro. This observation provides a rationale for further studies aiming to understand its mechanisms of action and its potent in vivo activity.
Keywords: chronic lymphocytic leukemia; docosahexaenoic acid chronic lymphocytic leukemia; docosahexaenoic acid

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MDPI and ACS Style

Guièze, R.; Gyan, E.; Tournilhac, O.; Halty, C.; Veyrat-Masson, R.; Akil, S.; Berger, M.; Hérault, O.; Callanan, M.; Bay, J.-O. Docosahexaenoic Acid Induces Apoptosis in Primary Chronic Lymphocytic Leukemia Cells. Hematol. Rep. 2015, 7, 6043. https://doi.org/10.4081/hr.2015.6043

AMA Style

Guièze R, Gyan E, Tournilhac O, Halty C, Veyrat-Masson R, Akil S, Berger M, Hérault O, Callanan M, Bay J-O. Docosahexaenoic Acid Induces Apoptosis in Primary Chronic Lymphocytic Leukemia Cells. Hematology Reports. 2015; 7(4):6043. https://doi.org/10.4081/hr.2015.6043

Chicago/Turabian Style

Guièze, Romain, Emmanuel Gyan, Olivier Tournilhac, Christelle Halty, Richard Veyrat-Masson, Saïda Akil, Marc Berger, Olivier Hérault, Mary Callanan, and Jacques-Olivier Bay. 2015. "Docosahexaenoic Acid Induces Apoptosis in Primary Chronic Lymphocytic Leukemia Cells" Hematology Reports 7, no. 4: 6043. https://doi.org/10.4081/hr.2015.6043

APA Style

Guièze, R., Gyan, E., Tournilhac, O., Halty, C., Veyrat-Masson, R., Akil, S., Berger, M., Hérault, O., Callanan, M., & Bay, J. -O. (2015). Docosahexaenoic Acid Induces Apoptosis in Primary Chronic Lymphocytic Leukemia Cells. Hematology Reports, 7(4), 6043. https://doi.org/10.4081/hr.2015.6043

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