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Hematology Reports
Volume 7
Issue 4
10.4081/hr.2015.6027
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Review

The Role of PTEN in Myeloid Malignancies

by
Alessandro Morotti
*,
Cristina Panuzzo
,
Sabrina Crivellaro
,
Giovanna Carrà
,
Davide Torti
,
Angelo Guerrasio
and
Giuseppe Saglio
Department of Clinical and Biological Sciences, University of Turin, San Luigi Hospital, Regione Gonzole 10, Orbassano, 10043 Turin, Italy
*
Author to whom correspondence should be addressed.
Hematol. Rep. 2015, 7(4), 6027; https://doi.org/10.4081/hr.2015.6027
Submission received: 21 May 2015 / Revised: 8 September 2015 / Accepted: 20 October 2015 / Published: 9 December 2015

Abstract

PTEN deletion in the mouse and in the zebrafish highlights the essential role of this tumor suppressor in the development of myeloid malignancies, in particular acute myeloid leukemia and myeloproliferative disorders. In humans, extensive genetic sequences of myeloid malignancies did not reveal recurrent PTEN mutations and deletions. However, PTEN was shown to be functionally inactivated in several acute myeloid leukemia and chronic myeloid leukemia samples, through both post-trasductional modifications, changes in protein levels and cellular compartmentalization. Notably, non genomic inactivation of PTEN in myeloid malignancies could represent a challenging therapeutic opportunity for these diseases. Targeting those mechanisms that affect PTEN function could indeed promote PTEN reactivation with consequent cancer selective apoptosis induction. In this review we will describe the role of PTEN in the development of myeloid malignancies.
Keywords: PTEN; acute myeloid leukemia; chronic myeloid leukemia; myeloproliferative disorders; myelodysplasia; murine models; zebrafish PTEN; acute myeloid leukemia; chronic myeloid leukemia; myeloproliferative disorders; myelodysplasia; murine models; zebrafish

Share and Cite

MDPI and ACS Style

Morotti, A.; Panuzzo, C.; Crivellaro, S.; Carrà, G.; Torti, D.; Guerrasio, A.; Saglio, G. The Role of PTEN in Myeloid Malignancies. Hematol. Rep. 2015, 7, 6027. https://doi.org/10.4081/hr.2015.6027

AMA Style

Morotti A, Panuzzo C, Crivellaro S, Carrà G, Torti D, Guerrasio A, Saglio G. The Role of PTEN in Myeloid Malignancies. Hematology Reports. 2015; 7(4):6027. https://doi.org/10.4081/hr.2015.6027

Chicago/Turabian Style

Morotti, Alessandro, Cristina Panuzzo, Sabrina Crivellaro, Giovanna Carrà, Davide Torti, Angelo Guerrasio, and Giuseppe Saglio. 2015. "The Role of PTEN in Myeloid Malignancies" Hematology Reports 7, no. 4: 6027. https://doi.org/10.4081/hr.2015.6027

APA Style

Morotti, A., Panuzzo, C., Crivellaro, S., Carrà, G., Torti, D., Guerrasio, A., & Saglio, G. (2015). The Role of PTEN in Myeloid Malignancies. Hematology Reports, 7(4), 6027. https://doi.org/10.4081/hr.2015.6027

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