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Hematology Reports
Volume 6
Issue 3
10.4081/hr.2014.5565
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Case Report

Posterior Reversible Encephalopathy Syndrome in a B-Cell Acute Lymphoblastic Leukemia Young Adult Patient Treated with a Pediatric-like Chemotherapeutic Schedule

by
Cristina Papayannidis
*,
Francesca Volpato
,
Ilaria Iacobucci
,
Maria Chiara Abbenante
,
Chiara Sartor
and
Giovanni Martinelli
Department of Experimental, Diagnostic and Specialty Medicine, Bologna University, Massarenti 9, 40138 Bologna, Italy
*
Author to whom correspondence should be addressed.
Hematol. Rep. 2014, 6(3), 5565; https://doi.org/10.4081/hr.2014.5565
Submission received: 21 July 2014 / Revised: 21 July 2014 / Accepted: 21 July 2014 / Published: 30 September 2014

Abstract

We report here the case of a young adult affected by pre B-cell acute lymphoblastic leukemia (ALL), who developed, during a pediatric-like chemotherapy consolidation schedule with high dosage of Methotrexate, a severe neurological toxicity. Clinical presentation and neuroimaging data were diagnostic for posterior reversible encephalopathy syndrome (PRES). A complete resolution was quickly obtained with medical blood pressure control and anticonvulsants administration. To the best of our knowledge, this is the first case of PRES described in the adult ALL setting. Currently, the clinical management of this aggressive disease is moving towards a pediatric-like approach also in adult patients, due to the better outcome reached with intensive chemotherapeutic regimens in children population. However, therapy-related toxicities have to be taken into account, since their onset may adversely affect patients’ clinical outcome.
Keywords: posterior reversible encephalopathy syndrome; acute lymphoblastic leukemia; methotrexate; seizure; brain magnetic resonance imaging posterior reversible encephalopathy syndrome; acute lymphoblastic leukemia; methotrexate; seizure; brain magnetic resonance imaging

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MDPI and ACS Style

Papayannidis, C.; Volpato, F.; Iacobucci, I.; Abbenante, M.C.; Sartor, C.; Martinelli, G. Posterior Reversible Encephalopathy Syndrome in a B-Cell Acute Lymphoblastic Leukemia Young Adult Patient Treated with a Pediatric-like Chemotherapeutic Schedule. Hematol. Rep. 2014, 6, 5565. https://doi.org/10.4081/hr.2014.5565

AMA Style

Papayannidis C, Volpato F, Iacobucci I, Abbenante MC, Sartor C, Martinelli G. Posterior Reversible Encephalopathy Syndrome in a B-Cell Acute Lymphoblastic Leukemia Young Adult Patient Treated with a Pediatric-like Chemotherapeutic Schedule. Hematology Reports. 2014; 6(3):5565. https://doi.org/10.4081/hr.2014.5565

Chicago/Turabian Style

Papayannidis, Cristina, Francesca Volpato, Ilaria Iacobucci, Maria Chiara Abbenante, Chiara Sartor, and Giovanni Martinelli. 2014. "Posterior Reversible Encephalopathy Syndrome in a B-Cell Acute Lymphoblastic Leukemia Young Adult Patient Treated with a Pediatric-like Chemotherapeutic Schedule" Hematology Reports 6, no. 3: 5565. https://doi.org/10.4081/hr.2014.5565

APA Style

Papayannidis, C., Volpato, F., Iacobucci, I., Abbenante, M. C., Sartor, C., & Martinelli, G. (2014). Posterior Reversible Encephalopathy Syndrome in a B-Cell Acute Lymphoblastic Leukemia Young Adult Patient Treated with a Pediatric-like Chemotherapeutic Schedule. Hematology Reports, 6(3), 5565. https://doi.org/10.4081/hr.2014.5565

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