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Hematology Reports
Volume 6
Issue 3
10.4081/hr.2014.5516
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Hematology Reports is published by MDPI from Volume 14 Issue 1 (2022). Previous articles were published by another publisher in Open Access under a CC-BY (or CC-BY-NC-ND) licence, and they are hosted by MDPI on mdpi.com as a courtesy and upon agreement with PAGEPress.
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Case Report

Azacitidine as Salvage Therapy for Acute Myeloid Leukemia in a Severely Ill Patient

by
Harry Ross Powers
1,
Moshe Bachar
1,
Natasha Savage
2,3,
Michael Toscano
2 and
Paul M. Dainer
3,4,*
1
Department of Medicine, Medical College of Georgia, Georgia Regents University, Augusta, GA, USA
2
Department of Pathology, Medical College of Georgia, Georgia Regents University, Augusta, GA, USA
3
Charlie Norwood Veteran Affairs Medical Center, Augusta, GA, USA
4
Section of Hematology/Oncology, Medical College of Georgia, Georgia Regents University, BAA-5407, 1120 15th Street, Augusta, GA 30912-3125, USA
*
Author to whom correspondence should be addressed.
Hematol. Rep. 2014, 6(3), 5516; https://doi.org/10.4081/hr.2014.5516
Submission received: 12 June 2014 / Revised: 6 August 2014 / Accepted: 19 August 2014 / Published: 30 September 2014

Abstract

Acute myeloid leukemia (AML) is a hematological malignancy of myeloid progenitor cells that disrupt normal hematopoiesis. Current chemotherapy regimens result in complete remission in many cases; however, there exists no standard efficacious therapy for refractory acute myeloid leukemia. The hypomethylating agent, azacitidine, is effective in a limited number of such cases. We present a 57-year-old Filipino male with acute myeloid leukemia who was refractory to two induction chemotherapy regimens; however, he achieved complete remission after palliative therapy with azacitidine. We report this case to demonstrate the efficacy of azacitidine in refractory acute myeloid leukemia. Although the effectiveness of azacitidine in improving overall survival has been shown, this case demonstrates the effect on remission induction in high risk AML. Further studies are needed to delineate subsets of acute myeloid leukemia in which azacitidine will serve as effective therapy and to identify other targeted agents that may potentiate its effects.
Keywords: leukemia; acute myeloblastic/monocytic/refractory; azacitidine; salvage chemotherapy leukemia; acute myeloblastic/monocytic/refractory; azacitidine; salvage chemotherapy

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MDPI and ACS Style

Powers, H.R.; Bachar, M.; Savage, N.; Toscano, M.; Dainer, P.M. Azacitidine as Salvage Therapy for Acute Myeloid Leukemia in a Severely Ill Patient. Hematol. Rep. 2014, 6, 5516. https://doi.org/10.4081/hr.2014.5516

AMA Style

Powers HR, Bachar M, Savage N, Toscano M, Dainer PM. Azacitidine as Salvage Therapy for Acute Myeloid Leukemia in a Severely Ill Patient. Hematology Reports. 2014; 6(3):5516. https://doi.org/10.4081/hr.2014.5516

Chicago/Turabian Style

Powers, Harry Ross, Moshe Bachar, Natasha Savage, Michael Toscano, and Paul M. Dainer. 2014. "Azacitidine as Salvage Therapy for Acute Myeloid Leukemia in a Severely Ill Patient" Hematology Reports 6, no. 3: 5516. https://doi.org/10.4081/hr.2014.5516

APA Style

Powers, H. R., Bachar, M., Savage, N., Toscano, M., & Dainer, P. M. (2014). Azacitidine as Salvage Therapy for Acute Myeloid Leukemia in a Severely Ill Patient. Hematology Reports, 6(3), 5516. https://doi.org/10.4081/hr.2014.5516

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