Hemophagocytic Lymphohistiocytosis and Pelger-Huët Anomaly Associated with Colchicine Intoxication

Baris Malbora; Emine Polat; Sare Gulfem Akyuz

doi:10.4081/hr.2014.5356

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Article

19 June 2014

Hemophagocytic Lymphohistiocytosis and Pelger-Huët Anomaly Associated with Colchicine Intoxication

and

Department of Pediatric Hematology, Dr. Sami Ulus Research and Training Hospital of Women's and Children’s Health and Diseases, Babur Caddesi 44, Ankara 06080, Turkey

Department of Pediatrics, Dr. Sami Ulus Research and Training Hospital of Women's and Children’s Health and Diseases, Ankara, Turkey

Department of Pediatric Nephrology, Dr. Sami Ulus Research and Training Hospital of Women's and Children’s Health and Diseases, Ankara, Turkey

Author to whom correspondence should be addressed.

Hematol. Rep.2014, 6(2), 5356;https://doi.org/10.4081/hr.2014.5356

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Abstract

Colchicine is frequently used in the treatment of familial Mediterranean fever (FMF). First symptoms of colchicine intoxication are gastrointestinal disturbances, such as abdominal cramps, diarrhea, pancytopenia and so on. Herein, we report a female FMF patient with pancytopenia and hemophagocytic lymphohitiocytosis (HLH), following colchicine intoxication for committing suicide. To our knowledge, this is the first reported case of a patient with HLH associated with colchicine intoxication.

Keywords:

colchicine intoxication; hemophagocytic lymphohitiocytosis; Pelger-Huët anomaly

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